1. Anti-infection
  2. Bacterial
  3. Ledaborbactam etzadroxil

Ledaborbactam etzadroxil (Synonyms: VNRX-7145)

Cat. No.: HY-132824
Handling Instructions

Ledaborbactam etzadroxil (VNRX-7145) is an orally active Ambler class A, C, and D β-lactamase enzymes inhibitor.

For research use only. We do not sell to patients.

Ledaborbactam etzadroxil Chemical Structure

Ledaborbactam etzadroxil Chemical Structure

CAS No. : 1842399-68-1

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Description

Ledaborbactam etzadroxil (VNRX-7145) is an orally active Ambler class A, C, and D β-lactamase enzymes inhibitor[1].

IC50 & Target

β-Lactamase[1]

In Vivo

Upon dosing the Ledaborbactam etzadroxil (VNRX-7145) in mice, dogs, and monkeys, Ledaborbactam etzadroxil (5-10 mg/kg) demonstrates the most consistent oral bioavailability across species (F = 61-82%)[1].
In intestinal S9, Ledaborbactam etzadroxil is rapidly cleaved with short half-lives in all species with the exception of beagle dogs. The half-life in human plasma is short at about 11 min, which is closer to what was observed in the rodent species compared to the longer half-lives in dogs (43.9 min) and monkeys (22.0 min)[1].
In vivo efficacy is demonstrated in a lethal murine septicemia model by dosing Ledaborbactam etzadroxil (orally) with Ceftibuten. The ED50 value of 12.9 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

391.22

Formula

C₁₉H₂₆BNO₇

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Ledaborbactam etzadroxil
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