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  4. Hypertension Models
  5. Uric acid

Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.

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No. CAS : 69-93-2

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Revisión del cliente

Based on 21 publication(s) in Google Scholar

Other Forms of Uric acid:

Uric acid Related Antibodies

Top Publications Citing Use of Products

    Uric acid purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(16):e2415041.  [Abstract]

    Immunofluorescence analysis of hair cells (HCs) with or without Uric acid (UA; 1, 2, 4 mM) at different concentrations for 24 h. Myosin 7a positive HCs are shown in red, and nuclei are labeled in blue.

    Uric acid purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2025 Oct 2;30(1):109.  [Abstract]

    The TEAC (top) and MDA content (bottom) were measured after co-treatment with RSL3 (MHCC97H: 0.5 µM; SJSA-1: 1 µM; LoVo: 5 µM) and Uric acid (UA; 500 µM) for 24 h. TEAC values were normalized to Trolox standards.

    Uric acid purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Sep 23:480:135938.  [Abstract]

    Representative Western blots of PPARγ and quantification of its protein level in different groups of HK2 cells with Uric acid (UA; 400 μM; 48 h).

    Uric acid purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Sep 23:480:135938.  [Abstract]

    Representative IF images of PPARγ (green)/DAPI (blue) in HK2 cells with Uric acid (UA; 400 μM; 48 h).

    Uric acid purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 Sep 23:480:135938.  [Abstract]

    Representative cell viability detected by CCK-8 in different groups of HK2 cells. Bixin (0-640 μM) without or with 400 μM Uric acid (UA) for 48 h.

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    Descripciòn

    Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

    IC50 & Target

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    0.3 mM
    Compound: 1175
    Substrate uptake by the Glucose Transporter Type 9 (GLUT9, SLC2A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC2A9 isoform 1
    Substrate uptake by the Glucose Transporter Type 9 (GLUT9, SLC2A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC2A9 isoform 1
    		10.5281/zenodo.7360607
    HEK293 EC50
    0.3 mM
    Compound: 1175
    Substrate uptake by the Glucose Transporter Type 9 (GLUT9, SLC2A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC2A9 isoform 1 (PubChem AID: 1794831)
    Substrate uptake by the Glucose Transporter Type 9 (GLUT9, SLC2A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC2A9 isoform 1 (PubChem AID: 1794831)
    		10.5281/zenodo.7360607
    In Vitro

    Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
    Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Uric acid Related Antibodies
    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Uric acid (250 mg/kg; p.o.) ameliorates indomethacin-induced enteropathy[2].
    Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Eight-week-old male C57BL/6J mice[2]
    Dosage: 250 mg/kg body weight
    Administration: P.o.
    Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
    Ensayo clínico
    Peso molecular

    168.11

    Fòrmula

    C5H4N4O3
    No. CAS
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(N1)NC2=C(NC(N2)=O)C1=O
    Structure Classification
    Initial Source
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvente y solubilidad
    In Vitro: 

    1M NaOH : 8.33 mg/mL (49.55 mM; ultrasonic and warming and adjust pH to 12 with 1M NaOH and heat to 60°C)

    H2O : 6.25 mg/mL (37.18 mM; ultrasonic and adjust pH to 11 with 1 M NaOH)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.9485 mL 29.7424 mL 59.4849 mL
    5 mM 1.1897 mL 5.9485 mL 11.8970 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 10 mg/mL (59.48 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Pureza y Documentación

    Purity: 99.92%

    SDS (396 KB)

    COA (249 KB) HNMR (252 KB) RP-HPLC (258 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / 1M NaOH 1 mM 5.9485 mL 29.7424 mL 59.4849 mL 148.7122 mL
    5 mM 1.1897 mL 5.9485 mL 11.8970 mL 29.7424 mL
    10 mM 0.5948 mL 2.9742 mL 5.9485 mL 14.8712 mL
    15 mM 0.3966 mL 1.9828 mL 3.9657 mL 9.9141 mL
    20 mM 0.2974 mL 1.4871 mL 2.9742 mL 7.4356 mL
    25 mM 0.2379 mL 1.1897 mL 2.3794 mL 5.9485 mL
    30 mM 0.1983 mL 0.9914 mL 1.9828 mL 4.9571 mL
    1M NaOH 40 mM 0.1487 mL 0.7436 mL 1.4871 mL 3.7178 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Uric acid Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Uric acid69-93-2Reactive Oxygen Species (ROS)Environmental PollutantsEndogenous MetaboliteEnvironmental Contaminantssingletoxygenperoxynitritelipidperoxidationantioxidantenteropathy oxidativestresscytotoxicityInhibitorinhibitorinhibit

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