69-93-2
69-93-2
Chemical Structure
Uric acid
- CAS No.: 69-93-2
- Formula:C5H4N4O3
- Molecular Weight:168.11
IUPAC Name: 7,9-dihydro-1H-purine-2,6,8(3H)-trione
InChIKey: LEHOTFFKMJEONL-UHFFFAOYSA-N
SMILES: O=C(N1)NC2=C(NC(N2)=O)C1=O
Biological Activity: Uric acid is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid can be used as a modeling agent in research on hyperuricemia-induced hypertension models[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Uric acid | 99.92% | Uric acid is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid can be used as a modeling agent in research on hyperuricemia-induced hypertension models. | ||||||||||||||||||||
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Uric acid (Standard) | 99.98% | Uric acid (Standard) is the analytical standard of Uric acid (HY-B2130). This product is intended for research and analytical applications. Uric acid is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid can be used as a modeling agent in research on hyperuricemia-induced hypertension models. | ||||||||||||||||||||
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Uric acid-13C,15N3 | 98.8% | Uric acid-13C,15N3 is the 15N, 13C-labeled Uric acid (HY-B2130). Uric acid is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid can be used as a modeling agent in research on hyperuricemia-induced hypertension models. | ||||||||||||||||||||
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Uric acid-15N2 | 99.95% | Uric acid-15N2 is the 15N-labeled Uric acid (HY-B2130). Uric acid is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid can be used as a modeling agent in research on hyperuricemia-induced hypertension models. | ||||||||||||||||||||
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Uric acid-13C | Uric acid-13C is the 13C-labeled Uric acid (HY-B2130). Uric acid is an orally active oxygen free radical scavenger that helps maintain stable blood pressure and combat oxidative stress. Uric acid can scavenge ROS, such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. Uric acid can be used as a modeling agent in research on hyperuricemia-induced hypertension models. | |||||||||||||||||||||
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8-Hydroxyguanine | 90.05% | 8-Hydroxyguanine is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine is a marker of DNA oxidative damage. | ||||||||||||||||||||
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8-Hydroxyguanine hydrochloride | 8-Hydroxyguanine hydrochloride is a DNA damage product under oxidative stress, which is formed when hydroxyl radicals attack guanine in DNA. 8-Hydroxyguanine hydrochloride induces mutagenesis and leads to a transversion from G to T. 8-Hydroxyguanine hydrochloride is a marker of DNA oxidative damage. | |||||||||||||||||||||
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3-Methyluric Acid-13C4,15N3 | 99.5% | 3-Methyluric Acid-13C4,15N3 is the 13C and 15N labeled 3-Methyluric Acid. | ||||||||||||||||||||
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2,8-Dihydroxyadenine | 97.29% | 2,8-Dihydroxyadenine is an endogenous metabolite that forms crystals in urine, leading to kidney stone formation and crystal deposition in the kidney. 2,8-Dihydroxyadenine induces crystal-induced tubular injury, inflammation, and fibrosis through crystal deposition in renal tubules, where crystals are excreted in urine, internalized by tubular epithelial cells, and transported to the interstitium. 2,8-Dihydroxyadenine upregulates CD44 expression near crystals, TNF-α signaling through NF-κB, and mTORC1 signaling, while inducing actin stress fiber formation and cytoskeletal remodeling. 2,8-Dihydroxyadenine downregulates epithelial-mesenchymal transition pathways and oxidative phosphorylation, and induces changes affecting inflammation, metabolism, and cell cycle regulation. 2,8-Dihydroxyadenine can be used in research on kidney disease, adenine phosphoribosyltransferase deficiency, and kidney stone disease. | ||||||||||||||||||||
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1-Methyluric acid-13C4,15N3 | 1-Methyluric acid-13C4,15N3 is the 13C and 15N labeled 1-Methyluric acid. 1-Methyluric acid acts on the urinary bladder mucosa and increases the blood glucose, insulin, triglyceride, and cholesterol levels. | |||||||||||||||||||||
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7-Methyluric acid | 99.9% | 7-Methyluric acid is a methylated purine metabolite of Theobromine (HY-N0138) and Caffeine. 7-Methyluric acid is a substrate of OAT1 (SLC22A6) and OAT3 (SLC22A8). 7-Methyluric acid is not transported by OATP1B1, OATP1B3, OCT2, MATE1, or P-glycoprotein. 7-Methyluric acid can be used in studies on urolithiasis. | ||||||||||||||||||||
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Uric acid-13C3 | Uric acid-13C3 is 13C-labeled Uric acid (HY-B2130). Uric acid is the end product of purine metabolism in the human body. Uric acid can scavenge reactive oxygen species (ROS), such as singlet oxygen and peroxynitrite, and inhibit lipid peroxidation. | |||||||||||||||||||||
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References
- [1]. Wang Q, et al. Recent Progress on Uric Acid Detection: A Review. Crit Rev Anal Chem. 2020;50(4):359-375. [Content Brief]
- [2]. Yasutake Y, et al. Uric acid ameliorates indomethacin-induced enteropathy in mice through its antioxidant activity. J Gastroenterol Hepatol. 2017 Nov;32(11):1839-1845. [Content Brief]
- [3]. Xu W F, et al. Hyperuricemia induces hypertension through activation of renal epithelial sodium channel (ENaC). Metabolism, 2016, 65(3): 73‑83.
