1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Yohimbine

Yohimbine 

Cat. No.: HY-12715 Purity: 98.10%
Handling Instructions

Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.

For research use only. We do not sell to patients.

Yohimbine Chemical Structure

Yohimbine Chemical Structure

CAS No. : 146-48-5

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Estimated Time of Arrival: December 31
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Based on 4 publication(s) in Google Scholar

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Description

Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM. IC50 value: 0.6 uM [1] Target: alpha 2-adrenergic receptor in vitro: Yohimbine inhibits alpha2-receptor antagonist with Ki of 1.05 nM, 1.19 nM, and 1.19 nM for α2A, α2B, α2C, respectively. Yohimbine also inhibits 5-HT1B with Ki of 19.9 nM. Yohimbine acts to block the lowering of cAMP by alpha-2 adrenoceptor agonists. yohimbine actually causes a pronounced lowering of tyrosinase activity. [3] in vivo: Yohimbine is an antagonist at alpha2-noradrenaline receptors with putative panicogenic effects in human subjects, was administered to Swiss-Webster mice at doses of 0.5, 1.0, and 2.0 mg/kg. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice.[2]

Clinical Trial
Molecular Weight

354.44

Formula

C₂₁H₂₆N₂O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (14.11 mM; Need ultrasonic)

H2O : 1 mg/mL (2.82 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8214 mL 14.1068 mL 28.2135 mL
5 mM 0.5643 mL 2.8214 mL 5.6427 mL
10 mM 0.2821 mL 1.4107 mL 2.8214 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Yohimbine
Cat. No.:
HY-12715
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