1. GPCR/G Protein
  2. Adrenergic Receptor

Yohimbine 

Cat. No.: HY-12715
Handling Instructions

Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM.

For research use only. We do not sell to patients.
Yohimbine Chemical Structure

Yohimbine Chemical Structure

CAS No. : 146-48-5

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Description

Yohimbine is a potent and relatively nonselective alpha 2-adrenergic receptor (AR) antagonist, with IC50 of 0.6 μM. IC50 value: 0.6 uM [1] Target: alpha 2-adrenergic receptor in vitro: Yohimbine inhibits alpha2-receptor antagonist with Ki of 1.05 nM, 1.19 nM, and 1.19 nM for α2A, α2B, α2C, respectively. Yohimbine also inhibits 5-HT1B with Ki of 19.9 nM. Yohimbine acts to block the lowering of cAMP by alpha-2 adrenoceptor agonists. yohimbine actually causes a pronounced lowering of tyrosinase activity. [3] in vivo: Yohimbine is an antagonist at alpha2-noradrenaline receptors with putative panicogenic effects in human subjects, was administered to Swiss-Webster mice at doses of 0.5, 1.0, and 2.0 mg/kg. Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice.[2]

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References
Molecular Weight

354.44

Formula

C₂₁H₂₆N₂O₃

CAS No.

146-48-5

SMILES

[H][[email protected]]12C(NC3=C4C=CC=C3)=C4CCN1C[[email protected]@]5(CC[[email protected]](O)[[email protected]](C(OC)=O)[[email protected]]5(C2)[H])[H]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Yohimbine
Cat. No.:
HY-12715
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