3-Methyl-L-histidine

Name: 3-Methyl-L-histidine
Brand: MedChemExpress
SKU: HY-W017007
Rating: 4.5 (0 reviews)

Cat. No.: HY-W017007 Pureza: 99.98%: Ficha de datos
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3-Methyl-L-histidine is an endogenous amino acid that can be found in actin and myosin.

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3-Methyl-L-histidine Estructura química

No. CAS : 368-16-1

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	En stock	Estimated Time of Arrival: December 31
Solid
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Other Forms of 3-Methyl-L-histidine:

3-Methyl-L-histidine-d₃ In-stock
3-Methyl-L-histidine-d₃ hydrochloride In-stock
3-Methyl-D-histidine-d₃ hydrochloride In-stock
3-Methyl-L-histidine (Standard) Obtener un presupuesto

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Human Endogenous Metabolite Microbial Metabolite

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Referencias
Revisión del cliente

Descripciòn

3-Methyl-L-histidine is an endogenous amino acid that can be found in actin and myosin^[1].

In Vitro

3-Methyl-L-histidine could be used as a robust, unequivocal index of that proportion of the total protein in food products derived from lean meat. 3-Methyl-L-histidine is absent from soya protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Adherence to high chicken protein diet (HCD) alleviated excessive weight gain and glycemic control regardless of the presence of gut microbiota in apolipoprotein E-deficient mice. In contrast, long-term HCD administration enhanced intestinal cholesterol absorption and accelerated atherosclerotic plaque formation in a gut microbiota-dependent manner. 3-Methyl-L-histidine results from an enrichment of Lachnospiraceae, as the key microbial effector to the atherogenic effect of HCD. 3-Methyl-L-histidine facilitates the binding of hepatocyte nuclear factor 1A (HNF1A) to the promoter of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

169.18

Fòrmula

C₇H₁₁N₃O₂

No. CAS

368-16-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CC1=CN=CN1C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

H₂O : 100 mg/mL (591.09 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9109 mL	29.5543 mL	59.1086 mL
5 mM	1.1822 mL	5.9109 mL	11.8217 mL
10 mM	0.5911 mL	2.9554 mL	5.9109 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (295.54 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.98%

Select Batch:

Ficha de datos (273 KB) SDS (393 KB)

COA (249 KB) HNMR (243 KB) RP-HPLC (205 KB) MS (68 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. White WJ, Lawrie RA. Variations in the levels of 3-methyl-l-histidine of the myosins within the bovine carcass. Meat Sci. 1985;15(3):173-81. [Content Brief]

[2]. Zhu S, et al. Microbiota-derived 3-Methyl-L-histidine mediates the proatherogenic effect of high chicken protein diet. MedComm (2020). 2025 Feb 13;6(2):e70090. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.9109 mL	29.5543 mL	59.1086 mL	147.7716 mL
	5 mM	1.1822 mL	5.9109 mL	11.8217 mL	29.5543 mL
	10 mM	0.5911 mL	2.9554 mL	5.9109 mL	14.7772 mL
	15 mM	0.3941 mL	1.9703 mL	3.9406 mL	9.8514 mL
	20 mM	0.2955 mL	1.4777 mL	2.9554 mL	7.3886 mL
	25 mM	0.2364 mL	1.1822 mL	2.3643 mL	5.9109 mL
	30 mM	0.1970 mL	0.9851 mL	1.9703 mL	4.9257 mL
	40 mM	0.1478 mL	0.7389 mL	1.4777 mL	3.6943 mL
	50 mM	0.1182 mL	0.5911 mL	1.1822 mL	2.9554 mL
	60 mM	0.0985 mL	0.4926 mL	0.9851 mL	2.4629 mL
	80 mM	0.0739 mL	0.3694 mL	0.7389 mL	1.8471 mL
	100 mM	0.0591 mL	0.2955 mL	0.5911 mL	1.4777 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.