2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 3-Methyl-L-histidine

3-Methyl-L-histidine  (Synonyms: 3-メチル-L-ヒスチジン)

製品番号: HY-W017007 純度: 99.98%
COA 取扱説明書 Technical Support

3-Methyl-L-histidine is an endogenous amino acid that can be found in actin and myosin.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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3-Methyl-L-histidine

3-Methyl-L-histidine 構造式

CAS 番号 : 368-16-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 99 在庫あり
Solution
10 mM * 1 mL in Water USD 99 在庫あり
Solid
100 mg $90 在庫あり
200 mg   お問い合わせ  
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Other Forms of 3-Methyl-L-histidine:

3-Methyl-L-histidine 関連抗体

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製品説明

3-Methyl-L-histidine is an endogenous amino acid that can be found in actin and myosin[1].

体外実験

3-Methyl-L-histidine could be used as a robust, unequivocal index of that proportion of the total protein in food products derived from lean meat. 3-Methyl-L-histidine is absent from soya protein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Methyl-L-histidine 関連抗体
体内実験

Adherence to high chicken protein diet (HCD) alleviated excessive weight gain and glycemic control regardless of the presence of gut microbiota in apolipoprotein E-deficient mice. In contrast, long-term HCD administration enhanced intestinal cholesterol absorption and accelerated atherosclerotic plaque formation in a gut microbiota-dependent manner. 3-Methyl-L-histidine results from an enrichment of Lachnospiraceae, as the key microbial effector to the atherogenic effect of HCD. 3-Methyl-L-histidine facilitates the binding of hepatocyte nuclear factor 1A (HNF1A) to the promoter of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

169.18

分子式

C7H11N3O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CC1=CN=CN1C
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (591.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9109 mL 29.5543 mL 59.1086 mL
5 mM 1.1822 mL 5.9109 mL 11.8217 mL
10 mM 0.5911 mL 2.9554 mL 5.9109 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (295.54 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.98%

COA (249 KB) HNMR (243 KB) RP-HPLC (205 KB) MS (68 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.9109 mL 29.5543 mL 59.1086 mL 147.7716 mL
5 mM 1.1822 mL 5.9109 mL 11.8217 mL 29.5543 mL
10 mM 0.5911 mL 2.9554 mL 5.9109 mL 14.7772 mL
15 mM 0.3941 mL 1.9703 mL 3.9406 mL 9.8514 mL
20 mM 0.2955 mL 1.4777 mL 2.9554 mL 7.3886 mL
25 mM 0.2364 mL 1.1822 mL 2.3643 mL 5.9109 mL
30 mM 0.1970 mL 0.9851 mL 1.9703 mL 4.9257 mL
40 mM 0.1478 mL 0.7389 mL 1.4777 mL 3.6943 mL
50 mM 0.1182 mL 0.5911 mL 1.1822 mL 2.9554 mL
60 mM 0.0985 mL 0.4926 mL 0.9851 mL 2.4629 mL
80 mM 0.0739 mL 0.3694 mL 0.7389 mL 1.8471 mL
100 mM 0.0591 mL 0.2955 mL 0.5911 mL 1.4777 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3-Methyl-L-histidine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Methyl-L-histidine368-16-1Endogenous MetaboliteInhibitorinhibitorinhibit

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