2. GPCR/G Protein MAPK/ERK Pathway Stem Cell/Wnt
  3. Prostaglandin Receptor p38 MAPK ERK
  4. AL-8810

AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

AL-8810

AL-8810 화학구조

CAS No. : 246246-19-5

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg   견적 받기  
10 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of AL-8810:

AL-8810 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AL-8810

View All Prostaglandin Receptor Isoform Specific Products:

View All Isoforms
DP EP FP IP TXA2/TP TXB2

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

AL-8810 is a potent and selective antagonist of the PGF 2α receptor (FP receptor). AL-8810 is an activator of MAPK and ERK1/2. The Ki of the FP receptor of mouse 3T3 cells and rat A7r5 cells are 0.2±0.06 μM and 0.4±0.1 μM, respectively. AL-8810 can be used in the study of elevated intraocular pressure (OHT) and primary open-angle glaucoma (POAG)[1][2][3][4][5].

In Vitro

AL-8810 (0.1, 1, 10 μM, 24 h) can significantly reduce the neuronal cell death of WT mice after OGD-induced injury[2].
AL-8810 (1, 10 μM, 24 h) promotes the activation of ERK1/2 in HEK 293 and MG-63 cells through epidermal growth factor receptor deactivation mechanism[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AL-8810 Related Antibodies

Western Blot Analysis[3]

Cell Line: HEK 293, MG-63
Concentration: 1, 10 μM
Incubation Time: 24 h
Result: Activated ERK1/2 and MAPK.
Activated MAPK through EGFR transactivation.
In Vivo

AL-8810 (1 or 10 mg/kg, intravenously) reduces ischemic brain injury and neurotoxicity in mice[2].
AL-8810 (10 mg/kg, intraperitoneal injection) can improve the prognosis after experimental traumatic brain injury in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Stroke mouse model[2]
Dosage: 1 or 10 mg/kg
Administration: i.v.
Result: Reduced the cortical infarct volume and tape-removal times.
Animal Model: Traumatic brain injury (TBI) model[5]
Dosage: 10 mg/kg
Administration: i.p.
Result: Improved neurological deficit scores (NDS) at 24 and 48 hours after controlled cortical impact (CCI).
분자량

402.50

화학식

C24H31FO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](C2CC3=C(C=CC=C3)C2)O)[C@@H](F)C[C@@H]1O
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : ≥ 10 mg/mL (24.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4845 mL 12.4224 mL 24.8447 mL
5 mM 0.4969 mL 2.4845 mL 4.9689 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 99.0%

SDS (251 KB)

COA (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4845 mL 12.4224 mL 24.8447 mL 62.1118 mL
5 mM 0.4969 mL 2.4845 mL 4.9689 mL 12.4224 mL
10 mM 0.2484 mL 1.2422 mL 2.4845 mL 6.2112 mL
15 mM 0.1656 mL 0.8282 mL 1.6563 mL 4.1408 mL
20 mM 0.1242 mL 0.6211 mL 1.2422 mL 3.1056 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AL-8810 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AL-8810246246-19-5AL8810AL 8810Prostaglandin Receptorp38 MAPKERKExtracellular signal regulated kinasesHEK 293MG-63Traumatic brain injuryStokeInhibitorinhibitorinhibit

최근 본 상품:

온라인 문의

Your information is safe with us. * Required Fields.

상품명

  

Requested Quantity *

고객명 *

 

호칭

메일주소 *

 

전화번호 *

Department

 

회사명 *

City

도

Country or Region *

      

비고

대량구매 문의

Inquiry Information

상품명:
AL-8810
Cat. No.:
HY-100449
수량:
MCE Japan Authorized Agent:

고객리뷰

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

상품명

  

Lot #

고객명 *

 

메일주소 *

전화번호

 

Department *

회사명 *

 

Country or Region *

비고

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.