2. Apoptosis
  3. Apoptosis
  4. Clodronic acid disodium salt

Clodronic acid (disodium salt)  (Synonyms: Clodronate (disodium salt))

製品番号: HY-B0657A Assay: 100.50%
COA 取扱説明書 Technical Support

Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis.

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Clodronic acid disodium salt

Clodronic acid (disodium salt) 構造式

CAS 番号 : 22560-50-5

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in Water USD 33 在庫あり
Solid
50 mg $30 在庫あり
100 mg $45 在庫あり
250 mg $81 在庫あり
500 mg   お問い合わせ  
1 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 4 publication(s) in Google Scholar

Other Forms of Clodronic acid disodium salt:

Clodronic acid (disodium salt) 関連抗体

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製品説明

Clodronic acid (Clodronate) disodium salt is an orally active bisphosphonate. Clodronic acid disodium salt inhibits osteoclast-mediated bone resorption. Clodronic acid disodium salt reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid disodium salt is effective in the maintenance or improvement of bone mineral density. Clodronic acid disodium salt can be used for the research of multiple myeloma and postmenopausal osteoporosis[1][2][3].

体外実験

Clodronic acid disodium salt induces rapid apoptosis in osteoclasts by preventing translocation of ADP into mitochondria after being internalised via resorption. Consequently, ATP production is inhibited, leading to induction of apoptosis by means of release of cytochrome C into the cytoplasm[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clodronic acid (disodium salt) 関連抗体
体内実験

Clodronic acid (6.25-25 mg/kg; p.o.; daily for 28 days) disodium salt slightly decreases the hindpaw swelling at doses of 12.5 and 25 mg/kg[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Lewis rats, aged 7 weeks[3]
Dosage: 6.25, 12.5, and 25 mg/kg
Administration: P.o.; daily for 28 days
Result: Hindpaw swelling was significantly smaller than in adjuvant-arthritis (AA)-control at 25 mg/kg on days 21 and 28 (87 and 88% of AA-control, respectively) and at 12.5 mg/kg on day 28.
分子量

288.86

分子式

CH2Cl2Na2O6P2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=P(C(Cl)(Cl)P(O)(O[Na])=O)(O)O[Na]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (346.19 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4619 mL 17.3094 mL 34.6188 mL
5 mM 0.6924 mL 3.4619 mL 6.9238 mL
10 mM 0.3462 mL 1.7309 mL 3.4619 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (346.19 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 100.50%

COA (248 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.4619 mL 17.3094 mL 34.6188 mL 86.5471 mL
5 mM 0.6924 mL 3.4619 mL 6.9238 mL 17.3094 mL
10 mM 0.3462 mL 1.7309 mL 3.4619 mL 8.6547 mL
15 mM 0.2308 mL 1.1540 mL 2.3079 mL 5.7698 mL
20 mM 0.1731 mL 0.8655 mL 1.7309 mL 4.3274 mL
25 mM 0.1385 mL 0.6924 mL 1.3848 mL 3.4619 mL
30 mM 0.1154 mL 0.5770 mL 1.1540 mL 2.8849 mL
40 mM 0.0865 mL 0.4327 mL 0.8655 mL 2.1637 mL
50 mM 0.0692 mL 0.3462 mL 0.6924 mL 1.7309 mL
60 mM 0.0577 mL 0.2885 mL 0.5770 mL 1.4425 mL
80 mM 0.0433 mL 0.2164 mL 0.4327 mL 1.0818 mL
100 mM 0.0346 mL 0.1731 mL 0.3462 mL 0.8655 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Clodronic acid disodium salt Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clodronic acid disodium22560-50-5Clodronate disodiumApoptosisfirst-generationosteoclasticboneresorptionPaget’smetastasesADPmitochondriacytochromeCInhibitorinhibitorinhibit

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