Copper tripeptide-3  (Synonyms: AHK-Cu)

Copper tripeptide-3 (AHK-Cu) is a bioactive peptide with promotion of hair growth effect. Copper tripeptide-3 increases dermal cell proliferation and viability while increasing the deposition of collagen to renew the extracellular matrix. Copper tripeptide-3 stimulates the elongation of human hair follicles and proliferation of dermal papilla cells^[1][2].

Copper tripeptide-3 (10-100 μM, 3 d) increases the growth and viability of dermal fibroblasts while stimulating the production of collagen in normal human dermal fibroblasts^[2].
Copper tripeptide-3 (10 pM-10 nM, 24 h) significantly stimulates the proliferation of cultured dermal papilla cells^[1].
Copper tripeptide-3 (10 nM, 72 h) reduces the number of apoptotic dermal papilla cells by 3.48%^[1].
Copper tripeptide-3 (10 nM, 24 h) increases Bcl-2 expression and decreases Bax expression in dermal papilla cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

415.93

C₁₅H₂₄CuN₆O₄

767286-83-9

Solid

Light blue to blue

Ala-His-{Lys-Cu}

AH-{Lys-Cu}

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Pyo HK, et al. The effect of tripeptide-copper complex on human hair growth in vitro. Arch Pharm Res. 2007;30(7):834-839.  [Content Brief]

  [2]. Patt L M, Procyte A. Neova® Refining Eye Lift Reduces the Appearance of Periorbital Wrinkles with DNA Repair and Copper Peptide Technologies[J]. skin, 2010, 1: 2.