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  3. CUDA

CUDA 

Cat. No.: HY-121538 Purity: >98.0%
Handling Instructions

CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease.

For research use only. We do not sell to patients.

CUDA Chemical Structure

CUDA Chemical Structure

CAS No. : 479413-68-8

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5 mg USD 365 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
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Description

CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].

IC50 & Target[1][2]

PPARα

 

mouse sEH

11.1 nM (IC50)

human sEH

112 nM (IC50)

In Vitro

CUDA (10 μM; 18 hours) produces 6- and 3-fold increases of PPARalpha in COS-7 cells[2].
CUDA does not alter PPARalpha protein expression, and it competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, suggesting that it functions as a PPARalpha ligand[2].

Western Blot Analysis[2]

Cell Line: COS-7 cells
Concentration: 10 μM
Incubation Time: 18 hours
Result: Activated PPARα by binding to the ligand binding domain of PPARα.
Molecular Weight

340.50

Formula

C₁₉H₃₆N₂O₃

CAS No.

479413-68-8

SMILES

O=C(NC1CCCCC1)NCCCCCCCCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

CUDAPPARPeroxisome proliferator-activated receptorsSolubleepoxidehydrolasesEHperoxisomeproliferator-activatedreceptorPPARalphaPPARαhypotensivelipid-loweringcardiovasculardiseaseInhibitorinhibitorinhibit

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CUDA
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