2. Metabolic Enzyme/Protease
    Cell Cycle/DNA Damage
    Vitamin D Related/Nuclear Receptor
  3. Epoxide Hydrolase
    PPAR
  4. CUDA

CUDA 

Cat. No.: HY-121538 Purity: ≥98.0%
COA Handling Instructions

CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease.

For research use only. We do not sell to patients.

CUDA Chemical Structure

CUDA Chemical Structure

CAS No. : 479413-68-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg USD 260 In-stock
Estimated Time of Arrival: December 31
100 mg USD 420 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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  • Customer Review

Description

CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].

IC50 & Target[1][2]

PPARα

 

mouse sEH

11.1 nM (IC50)

human sEH

112 nM (IC50)

In Vitro

CUDA (10 μM; 18 hours) produces 6- and 3-fold increases of PPARalpha in COS-7 cells[2].
CUDA does not alter PPARalpha protein expression, and it competitively inhibits the binding of Wy-14643 (pirinixic acid) to the ligand binding domain of PPARalpha, suggesting that it functions as a PPARalpha ligand[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: COS-7 cells
Concentration: 10 μM
Incubation Time: 18 hours
Result: Activated PPARα by binding to the ligand binding domain of PPARα.
Molecular Weight

340.50

Appearance

Solid

Formula

C19H36N2O3
CAS No.
SMILES

O=C(NC1CCCCC1)NCCCCCCCCCCCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (73.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9369 mL 14.6843 mL 29.3686 mL
5 mM 0.5874 mL 2.9369 mL 5.8737 mL
10 mM 0.2937 mL 1.4684 mL 2.9369 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.47 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (239 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

CUDA479413-68-8Epoxide HydrolasePPARPeroxisome proliferator-activated receptorsSolubleepoxidehydrolasesEHperoxisomeproliferator-activatedreceptorPPARalphaPPARαhypotensivelipid-loweringcardiovasculardiseaseInhibitorinhibitorinhibit

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