DCG-IV

Name: DCG-IV
Brand: MedChemExpress
SKU: HY-101335
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-101335 Reinheit: 98.9%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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DCG-IV is a potent agonist of group II mGluRs with EC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.

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DCG-IV Chemische Struktur

CAS. Nr. : 147782-19-2

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle mGluR Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

Biologische Aktivität
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Beschreibung

IC₅₀ & Target^[1]

mGluR2R

0.35 μM (EC₅₀)

mGluR3R

0.09 μM (EC₅₀)

mGluR1R

389 μM (IC₅₀)

mGluR5

630 μM (IC₅₀)

mGluR4R

22.5 μM (IC₅₀)

mGluR6

39.6 μM (IC₅₀)

mGluR7

40.1 μM (IC₅₀)

mGluR8

32 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	389 3 Compound: 19	Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells. Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.	[PMID: 10229625]
HEK293	EC₅₀	45 1 Compound: DCG-IV	Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader	[PMID: 20218620]
HEK293	EC₅₀	45 1 Compound: DCG-IV	Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader	[PMID: 20218620]
HEK293	EC₅₀	45 1 Compound: DCG-IV	Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader	[PMID: 20218620]
HEK293	IC₅₀	389 3 Compound: 19	Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells. Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells.	[PMID: 10229625]

In Vitro

DCG-IV is also an NMDA receptor agonist in the rat cortical slice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR mice weighing about 40 g (PCP-induced locomotor activity)^[4]
Dosage:	10, 5, or 1 mg/kg
Administration:	I.p.
Result:	Reduced spontaneous activities of the animals at 10 or 5 mg/kg.

Molekulargewicht

203.15

Formel

C₇H₉NO₆

CAS. Nr.

147782-19-2

Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1[C@H](C(O)=O)C1[C@H](N)C(O)=O)O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : ≥ 20 mg/mL (98.45 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9225 mL	24.6124 mL	49.2247 mL
5 mM	0.9845 mL	4.9225 mL	9.8449 mL
10 mM	0.4922 mL	2.4612 mL	4.9225 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 99.0%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (250 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Brabet I, et al. Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all clonedmetabotropic glutamate receptor subtypes. Neuropharmacology. 1998 Aug;37(8):1043-51. [Content Brief]

[2]. Bertrand HO, et al. Common and selective molecular determinants involved in metabotopic glutamate receptoragonist activity. J Med Chem. 2002 Jul 18;45(15):3171-83. [Content Brief]

[3]. Uyama Y, et al. DCG-IV, a potent metabotropic glutamate receptor agonist, as an NMDA receptor agonist in the rat cortical slice. Brain Res. 1997 Mar 28;752(1-2):327-30. [Content Brief]

[4]. Tomita N, et al. The effects of DCG-IV and L-CCG-1 upon phencyclidine (PCP)-induced locomotion and behavioral changes in mice. Ann N Y Acad Sci. 2000 Sep;914:284-91. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	4.9225 mL	24.6124 mL	49.2247 mL	123.0618 mL
	5 mM	0.9845 mL	4.9225 mL	9.8449 mL	24.6124 mL
	10 mM	0.4922 mL	2.4612 mL	4.9225 mL	12.3062 mL
	15 mM	0.3282 mL	1.6408 mL	3.2816 mL	8.2041 mL
	20 mM	0.2461 mL	1.2306 mL	2.4612 mL	6.1531 mL
	25 mM	0.1969 mL	0.9845 mL	1.9690 mL	4.9225 mL
	30 mM	0.1641 mL	0.8204 mL	1.6408 mL	4.1021 mL
	40 mM	0.1231 mL	0.6153 mL	1.2306 mL	3.0765 mL
	50 mM	0.0984 mL	0.4922 mL	0.9845 mL	2.4612 mL
	60 mM	0.0820 mL	0.4102 mL	0.8204 mL	2.0510 mL
	80 mM	0.0615 mL	0.3077 mL	0.6153 mL	1.5383 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

DCG-IV Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCG-IV147782-19-2mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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DCG-IV

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DCG-IV Related Antibodies

Spezialitätsempfehlungen

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DCG-IV Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

DCG-IV Related Classifications

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