2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Dephospho-CoA

Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed to form CoA by GTP-dependent Dephospho-CoA kinase (DPCK). Dephospho-CoA completes the final synthetic step of CoA via phosphorylation and participates in energy metabolism and cellular signal transduction. Dephospho-CoA can be used in studies involving cancer (e.g., regulation of cell proliferation) and metabolic diseases (e.g., mitochondrial dysfunction).

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Dephospho-CoA

Dephospho-CoA 構造式

CAS 番号 : 3633-59-8

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Based on 1 publication(s) in Google Scholar

Dephospho-CoA 関連抗体

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製品説明

Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed to form CoA by GTP-dependent Dephospho-CoA kinase (DPCK). Dephospho-CoA completes the final synthetic step of CoA via phosphorylation and participates in energy metabolism and cellular signal transduction. Dephospho-CoA can be used in studies involving cancer (e.g., regulation of cell proliferation) and metabolic diseases (e.g., mitochondrial dysfunction)[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外実験

Dephospho-CoA (10 min) is quantitatively phosphorylated to CoA by DPCK, as confirmed by reverse-phase HPLC analysis of reaction products[1].
Dephospho-CoA (1 mM; 80 °C incubation for standard/kinetic assays; 70 °C incubation for specificity assays; 2 h preincubation for thermostability assays) was specifically phosphorylated to CoA by purified recombinant Thermococcus kodakarensis TK1697 protein, a GTP-dependent DPCK with optimal activity at 80 °C and pH 8.0, high thermostability, and a catalytic efficiency (kcat/Km) of 40.4 s−1 mM−1 for dephospho-CoA[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dephospho-CoA 関連抗体
分子量

687.55

分子式

C21H35N7O13P2S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](OCC(C)(C)[C@@H](O)C(NCCC(NCCS)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 50 mg/mL (72.72 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4544 mL 7.2722 mL 14.5444 mL
5 mM 0.2909 mL 1.4544 mL 2.9089 mL
10 mM 0.1454 mL 0.7272 mL 1.4544 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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In Vivo Dissolution Calculator
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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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純度とドキュメンテーション

純度: 96%

COA (244 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.4544 mL 7.2722 mL 14.5444 mL 36.3610 mL
5 mM 0.2909 mL 1.4544 mL 2.9089 mL 7.2722 mL
10 mM 0.1454 mL 0.7272 mL 1.4544 mL 3.6361 mL
15 mM 0.0970 mL 0.4848 mL 0.9696 mL 2.4241 mL
20 mM 0.0727 mL 0.3636 mL 0.7272 mL 1.8180 mL
25 mM 0.0582 mL 0.2909 mL 0.5818 mL 1.4544 mL
30 mM 0.0485 mL 0.2424 mL 0.4848 mL 1.2120 mL
40 mM 0.0364 mL 0.1818 mL 0.3636 mL 0.9090 mL
50 mM 0.0291 mL 0.1454 mL 0.2909 mL 0.7272 mL
60 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.6060 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dephospho-CoA Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dephospho-CoA3633-59-8Endogenous Metabolitehuman DPCK/phosphopantetheine adenylyltransferasemalonyl thioester derivativesreverse-phase HPLCacetyl thioester derivativesdephospho-CoA kinasedephospho-CoAE. coliTK1697coenzyme AThermococcus kodakarensisInhibitorinhibitorinhibit

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製品名:
Dephospho-CoA
製品番号:
HY-137899
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