3633-59-8
Chemical Structure
Dephospho-CoA
- CAS No.: 3633-59-8
- Formula:C21H35N7O13P2S
- Molecular Weight:687.55
InChIKey: KDTSHFARGAKYJN-IBOSZNHHSA-N
SMILES: O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](OCC(C)(C)[C@@H](O)C(NCCC(NCCS)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2
Biological Activity: Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed to form CoA by GTP-dependent Dephospho-CoA kinase (DPCK). Dephospho-CoA completes the final synthetic step of CoA via phosphorylation and participates in energy metabolism and cellular signal transduction. Dephospho-CoA can be used in studies involving cancer (e.g., regulation of cell proliferation) and metabolic diseases (e.g., mitochondrial dysfunction)[1][2].
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Dephospho-CoA | 96% | Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed to form CoA by GTP-dependent Dephospho-CoA kinase (DPCK). Dephospho-CoA completes the final synthetic step of CoA via phosphorylation and participates in energy metabolism and cellular signal transduction. Dephospho-CoA can be used in studies involving cancer (e.g., regulation of cell proliferation) and metabolic diseases (e.g., mitochondrial dysfunction). | ||||||||||||||||||||
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- [1]. Wadler C, et al. Dephospho-CoA kinase provides a rapid and sensitive radiochemical assay for coenzyme A and its thioesters. Anal Biochem. 2007;368(1):17-23. [Content Brief]
- [2]. Shimosaka T, et al. Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea. mBio. 2019;10(4):e01146-19. Published 2019 Jul 23. [Content Brief]
Keywords
