Diphenidol 

Diphenidol is a non-selective muscarinic M₁-M₄ receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na⁺, K⁺, and Ca²⁺) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea^{[1][2][3][4][5]}.

Diphenidol inhibits sodium currents and produces spinal anesthesia, and at -70 and -100 mV holding potentials, N2A cells IC₅₀ were 0.77 and 62.6 μM^{, respectively [3].}

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diphenidol (2, 10 μmoL/kg, intraperitoneal injection) is used to reduce neuropathic pain and TNF-α overexpression in rats after chronic systolic injury^[4].
Diphenidol (30 mg/kg, injected intravenously) has an inhibitory effect on exercise and morphine-induced vomiting in pica rats^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

309.45

C₂₁H₂₇NO

972-02-1

OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44.  [Content Brief]

  [2]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.  [Content Brief]

  [3]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.  [Content Brief]

  [4]. Chen YW, et al. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5.  [Content Brief]

  [5]. Takeda N, et al. Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995 Nov;17(9):589-90.  [Content Brief]