1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. mAChR
    Sodium Channel
  3. Diphenidol hydrochloride

Diphenidol hydrochloride (Synonyms: Difenidol hydrochloride)

Cat. No.: HY-A0082 Purity: 99.0%
Handling Instructions

Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells.

For research use only. We do not sell to patients.

Diphenidol hydrochloride Chemical Structure

Diphenidol hydrochloride Chemical Structure

CAS No. : 3254-89-5

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Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 72 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Description

Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells[1][2].

Molecular Weight

345.91

Formula

C₂₁H₂₈ClNO

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 46 mg/mL (132.98 mM)

H2O : 16.67 mg/mL (48.19 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8909 mL 14.4546 mL 28.9093 mL
5 mM 0.5782 mL 2.8909 mL 5.7819 mL
10 mM 0.2891 mL 1.4455 mL 2.8909 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Diphenidol hydrochloride
Cat. No.:
HY-A0082
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