1. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  2. mAChR Sodium Channel
  3. Diphenidol hydrochloride

Diphenidol hydrochloride  (Synonyms: Difenidol hydrochloride)

Cat. No.: HY-A0082 Purity: 99.95%
COA Handling Instructions

Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea.

For research use only. We do not sell to patients.

Diphenidol hydrochloride Chemical Structure

Diphenidol hydrochloride Chemical Structure

CAS No. : 3254-89-5

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

Diphenidol hydrochloride (Difenidol hydrochloride) is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol hydrochloride is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol hydrochloride can be used in the study of antivertigo and antinausea[1][2][3][4][5].

IC50 & Target

mAChR3

 

mAChR2

 

mAChR1

 

mAChR4

 

In Vitro

Diphenidol hydrochloride inhibits sodium currents and produces spinal anesthesia, and at -70 and -100 mV holding potentials, N2A cells IC50 were 0.77 and 62.6 μM, respectively [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Diphenidol hydrochloride (2, 10 μmoL/kg, intraperitoneal injection) is used to reduce neuropathic pain and TNF-α overexpression in rats after chronic systolic injury[4].
Diphenidol hydrochloride (30 mg/kg, injected intravenously) has an inhibitory effect on exercise and morphine-induced vomiting in pica rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronic constriction injury (CCI) rat model[4]
Dosage: 2, 10 μmoL/kg
Administration: i.p., berore surgery, and on postoperative days 3, 6, 7, 11, 13 and 14.
Result: Increased mechanical withdrawal threshold in a dose-dependent manner and decreased the TNF-α level.
Molecular Weight

345.91

Formula

C21H28ClNO

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 46 mg/mL (132.98 mM)

H2O : 16.67 mg/mL (48.19 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8909 mL 14.4546 mL 28.9093 mL
5 mM 0.5782 mL 2.8909 mL 5.7819 mL
10 mM 0.2891 mL 1.4455 mL 2.8909 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.23 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Diphenidol hydrochloride
Cat. No.:
HY-A0082
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