1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Ipratropium bromide

Ipratropium bromide (Synonyms: Sch 1000)

Cat. No.: HY-B0241 Purity: ≥98.0%
Handling Instructions

Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma.

For research use only. We do not sell to patients.

Ipratropium bromide Chemical Structure

Ipratropium bromide Chemical Structure

CAS No. : 22254-24-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 68 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 68 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 62 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Ipratropium bromide (Sch 1000) is a muscarinic receptor antagonist, with binding IC50 values of 2.9 nM, 2 nM, and 1.7 nM for M1, M2, and M3 receptors, respectively. Ipratropium bromide can be used in the research for COPD (chronic obstructive pulmonary disease) and asthma[1][2][3].

In Vivo

Ipratropium bromide (0.01-1.0 μg/kg) potentiates vagally induces bronchoconstriction[2].
Ipratropium bromide (0.04 mg/20 mL and 0.20 mg/20 mL) can protect the lungs against the cadmium-induced acute neutrophilic inflammation by reducing the parenchyma inflammatory infiltration of neutrophils[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Guinea-pigs of the Dunkin Hartley strain[2].
Dosage: 0.1-1 μg/kg.
Administration: Injected intraperitoneally.
Result: 0.3 μg/kg had little blocking effect on post-junctional muscarinic receptors while doses greater than 0.5 μg/kg inhibited ACh-induced bronchoconstriction.
Animal Model: Male Sprague-Dawley rats (n = 114) weighing between 300 and 350 g[4].
Dosage: 0.04 mg/20 mL and 0.20 mg/20 mL.
Administration: Inhalation.
Result: Had no significant effects on any parameters recorded in healthy rats but exerted a protective effect against the inflammatory reaction elicited by cadmium.
Clinical Trial
Molecular Weight

412.36

Formula

C₂₀H₃₀BrNO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (242.51 mM; Need ultrasonic)

DMSO : ≥ 35 mg/mL (84.88 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4251 mL 12.1253 mL 24.2507 mL
5 mM 0.4850 mL 2.4251 mL 4.8501 mL
10 mM 0.2425 mL 1.2125 mL 2.4251 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Ipratropium bromide
Cat. No.:
HY-B0241
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