972-02-1
972-02-1
Chemical Structure
Diphenidol
- CAS No.: 972-02-1
- Formula:C21H27NO
- Molecular Weight:309.45
IUPAC Name: 1,1-diphenyl-4-(piperidin-1-yl)butan-1-ol
InChIKey: OGAKLTJNUQRZJU-UHFFFAOYSA-N
SMILES: OC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCCCC3
Biological Activity: Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea[1][2][3][4][5].
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Diphenidol | Diphenidol is a non-selective muscarinic M1-M4 receptor antagonist, has anti-arrhythmic activity. Diphenidol is also a potent non-specific blocker of voltage-gated ion channels (Na+, K+, and Ca2+) in neuronal cells. Diphenidol can be used in the study of antivertigo and antinausea. | |||||||||||||||||||||
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Diphenadol-d10 | Diphenadol-d10 is deuterium labeled Diphenadol. | |||||||||||||||||||||
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References
- [1]. Leung YM, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44. [Content Brief]
- [2]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52. [Content Brief]
- [3]. Leung YM, et al. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52. [Content Brief]
- [4]. Chen YW, et al. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5. [Content Brief]
- [5]. Takeda N, et al. Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats. Methods Find Exp Clin Pharmacol. 1995 Nov;17(9):589-90. [Content Brief]
