2. Metabolic Enzyme/Protease Apoptosis Immunology/Inflammation
  3. Dipeptidyl Peptidase TNF Receptor Interleukin Related
  4. DPP-4-IN-8

DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a Ki of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β).

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DPP-4-IN-8

DPP-4-IN-8 Estructura química

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DPP-4-IN-8 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas Dipeptidyl Peptidase:

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

Ver todos los productos específicos de isoformas TNF Receptor:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

Ver todos los productos específicos de isoformas Interleukin Related:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Descripciòn

DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a Ki of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β)[1].

IC50 & Target

DPP-4

0.96 μM (Ki)

IL-6

 

IL-1β

 

In Vitro

DPP-4-IN-8 (compound 27) shows no toxicity to normal cells and weak toxicity to cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DPP-4-IN-8 Related Antibodies
Peso molecular

349.72

Fòrmula

C16H12ClNO6
SMILES

[O-][N+](C1=CC(C(/C=C/C2=C(OC)C=C(O)C(Cl)=C2)=O)=CC=C1O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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DPP-4-IN-8 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DPP-4-IN-8Dipeptidyl PeptidaseTNF ReceptorInterleukin RelatedDPPTumor Necrosis Factor ReceptorTNFRILCaco-2HepG-2Inhibitorinhibitorinhibit

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Nombre del producto:
DPP-4-IN-8
Cat. No.:
HY-155027
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