Erythromycin propionate 

Erythromycin propionate, erythromycin (HY-B0220) derivative^[1], is a macrolide antibiotic used in the treatment of a wide variety of bacterial infections. Erythromycin propionate causes several cases of liver injury which mostly include cholestatic hepatitis. Erythromycin propionate toxicity is related to its inhibitory effect on bile acid transport^[2].

Erythromycin propionate inactivates viral particles by destroying the integrity of the viral membrane, resulting in the release of viral genomic RNA, and the irreversible loss of infection ability. Erythromycin propionate inhibits various flaviviruses, including Zika virus (ZIKV), dengue virus (DENV), yellow fever virus (YFV) and human coronavirus OC43 (HCoV-OC43)^[2].
Erythromycin propionate (2.5-10 µM, 48 h) reduces the virus titer of HCoV-OC43 with an IC₅₀ of 1.40 µM, reduces the number of HCoV-OC43 infected BHK-21 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Erythromycin propionate (450-1200 mg/kg, po, once daily for 7 days) activates alanine aminotransferase (ALT), induces oxidative stress, and exhibits hepatotoxicity in Wistar rats models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

789.99

C₄₀H₇₁NO₁₄

134-36-1

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Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zimmerman HJ, et al. Studies on the vitro cytotoxicity of erythromycin estolate. Proc Soc Exp Biol Med. 1973 Dec;144(3):759-61.  [Content Brief]