2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Folitixorin

Folitixorin  (Synonyms: 5,10-Methylenetetrafolate; ANX-510 free acid)

製品番号: HY-14769 純度: 80.59%
COA 取扱説明書 Technical Support

Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research.

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Folitixorin

Folitixorin 構造式

CAS 番号 : 3432-99-3

容量 価格（税別） 在庫状況 数量
1 mg $280 在庫あり
5 mg $785 在庫あり
10 mg $1300 在庫あり
25 mg $2730 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

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Based on 2 publication(s) in Google Scholar

Other Forms of Folitixorin:

Folitixorin 関連抗体

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製品説明

Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2].

体外実験

5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate into 5-methyltetrahy-drofolate, which is the major circulating form of folate[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Folitixorin 関連抗体
体内実験

A colon adenocarcinoma cell suspension is inoculated intrahepatically in a rodent experimental model. Intravenous 5-FU (30 mg/kg) in combination with Folitixorin (15 mg/kg or 30 mg/kg) is administered after 1, 2, 3, 4 and 7 days. 5-FU in combination with Folitixorin (regardless of folate-dose) eliminats tumor take[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

457.44

分子式

C20H23N7O6
CAS 番号
Appearance

Solid

Color

White to yellow

SMILES

O=C1C2=C(NCC3N2CN(C4=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C4)C3)NC(N)=N1
Structure Classification
Initial Source
輸送条件

Shipping with dry ice.
保管条件

-80°C, protect from light, stored under nitrogen
溶剤 & 溶解度
体外: 

H2O : 5 mg/mL (10.93 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1861 mL 10.9304 mL 21.8608 mL
5 mM 0.4372 mL 2.1861 mL 4.3722 mL
10 mM 0.2186 mL 1.0930 mL 2.1861 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.1861 mL 10.9304 mL 21.8608 mL 54.6520 mL
5 mM 0.4372 mL 2.1861 mL 4.3722 mL 10.9304 mL
10 mM 0.2186 mL 1.0930 mL 2.1861 mL 5.4652 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Folitixorin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Folitixorin3432-99-35,10-MethylenetetrafolateANX-510ANX510ANX 510Endogenous Metabolitefolatereductaserodent5-FUtumorcolonadenocarcinomacofactorInhibitorinhibitorinhibit

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製品番号:
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