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Cat. No.: HY-14769A

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Folitixorin calcium

(Synonyms: 5,10-Methylenetetrafolate calcium; ANX-510)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Folitixorin calcium is a cofactor and an analog of leucovorin. Folitixorin calcium is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research.

For research use only. We do not sell to patients.

CAS No.: 133978-75-3
Formula: C₂₀H₂₁CaN₇O₆
Molecular Weight:495.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Folitixorin calcium Chemical Structure

CAS No.: 133978-75-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Folitixorin calcium is a cofactor and an analog of leucovorin. Folitixorin calcium is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research^[1]^[2].

All Endogenous Metabolite Isoforms :

Chemical Information

CAS No. 133978-75-3
Molecular Weight 495.50
Formula C₂₀H₂₁CaN₇O₆
SMILES

O=C1C2=C(NCC3N2CN(C4=CC=C(C(N[C@]([H])(C([O-])=O)CCC([O-])=O)=O)C=C4)C3)NC(N)=N1.[Ca+2]
Synonyms

5,10-Methylenetetrafolate calcium; ANX-510
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Nat Commun

Nuclear localization of MTHFD2 is required for correct mitosis progression. [Abstract]

2024 Nov 12;15(1):9529. PMID: 39532843
bioRxiv

2023 Jun 1.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Costantini CL, et al. Resection of hepatic metastasis after 5-fluorouracil and cofactor for colon cancer. Hepatogastroenterology. 2009;56(91-92):645-649. [Content Brief]

[2]. Carlsson G, et al. 5-fluorouracil (5-FU) and 5,10-methylene tetrahydrofolate (5,10-CH2FH4) as adjuvant therapy in an experimental rodent colon carcinoma model. Anticancer Res. 1997;17(5A):3671-3674. [Content Brief]

[3]. Botto LD, et al. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000;151(9):862-877. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Folitixorin calcium

2 Cited Publications

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Folitixorin calcium

Publications Citing Use of MedChemExpress (MCE) Folitixorin calcium

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

Folitixorin calcium Related Classifications

HY-14769A Related Classifications