Folitixorin
Based on 2 publication(s) in Google Scholar
Folitixorin (5,10-Methylenetetrafolate; ANX-510 free acid) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 80.59%
- CAS No.: 3432-99-3
- Formula: C20H23N7O6
- Molecular Weight:457.44
-
Storage:
-80°C, protect from light, stored under nitrogen
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-14520
Tetrahydrofolic acid -
HY-B1342
Vitamin A -
HY-14781
Levomefolic acid -
HY-137808
Succinyl-Coenzyme A sodium -
HY-111914A
Ferroheme -
HY-B2209
Hydroxocobalamin -
HY-113269
alpha-CEHC -
HY-17556
Folinic acid -
HY-113046
5-Methyltetrahydrofolic acid -
HY-15162
Monomethyl auristatin E -
HY-112169A
10-Formyltetrahydrofolic acid disodium -
HY-119722
Butafosfan
Publications Citing Use of MedChemExpress (MCE) Folitixorin
More
Biological Activity
Description
In Vitro
Folitixorin (1000 ns) forms structurally conserved stable complexes with human thymidylate synthase and Klebsiella pneumoniae thymidylate synthase [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:6-8 week old nude mice (nu/nu) with 2 x 106 HT-29 cells[3]
-
Dosage:0.6 mg/mouse/drug ( 5-FU, Leucovorin, and αVEGF)
-
Administration:i.p., daily, five consecutive days with the exception of αVEGF, dosed once (100 μg/mouse) on day 1
-
Result:Reduced tumor volume and improved survival rate in a colorectal tumor model of nude mice.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 3432-99-3
-
Appearance Solid
-
Molecular Weight 457.44
-
Formula C20H23N7O6
-
Color White to yellow
-
SMILES
O=C1C2=C(NCC3N2CN(C4=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C4)C3)NC(N)=N1
-
Synonyms
5,10-Methylenetetrafolate; ANX-510 free acid
-
Structure Classification
-
Initial Source
-
Shipping
Shipping with dry ice.
-
Storage
-80°C, protect from light, stored under nitrogen
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
2024 Nov 12;15(1):9529. PMID: 39532843 -
Solvent & Solubility
In Vitro:
H2O : 5 mg/mL (10.93 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (285 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.1861 mL | 10.9304 mL | 21.8608 mL | 54.6520 mL |
| 5 mM | 0.4372 mL | 2.1861 mL | 4.3722 mL | 10.9304 mL | |
| 10 mM | 0.2186 mL | 1.0930 mL | 2.1861 mL | 5.4652 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Folitixorin Related Classifications
HY-14769 Related Classifications
Powered by Bioz
Keywords
- Folitixorin
- 3432-99-3
- 5,10-Methylenetetrafolate
- ANX-510
- ANX510
- ANX 510
- Thymidylate Synthase
- Klebsiella pneumoniae thymidylate synthase
- ascitic Yoshida sarcoma cells
- colorectal cancer
- ascitic P-388 leukemia cells
- FdUMP
- p-388 leukemia
- human thymidylate synthase
- thymidylate synthase
- yoshida sarcoma
- Inhibitor
- inhibitor
- inhibit