1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Folitixorin

Folitixorin (Synonyms: 5,10-Methylenetetrafolate; ANX-510 free acid)

Cat. No.: HY-14769
Handling Instructions

Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research.

For research use only. We do not sell to patients.

Folitixorin Chemical Structure

Folitixorin Chemical Structure

CAS No. : 3432-99-3

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Description

Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2].

In Vitro

5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate into 5-methyltetrahy-drofolate, which is the major circulating form of folate[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A colon adenocarcinoma cell suspension is inoculated intrahepatically in a rodent experimental model. Intravenous 5-FU (30 mg/kg) in combination with Folitixorin (15 mg/kg or 30 mg/kg) is administered after 1, 2, 3, 4 and 7 days. 5-FU in combination with Folitixorin (regardless of folate-dose) eliminats tumor take[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

457.44

Formula

C₂₀H₂₃N₇O₆

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Folitixorin
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