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Cat. No.: HY-14769B

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Folitixorin sodium

Name: Folitixorin sodium
Brand: MedChemExpress
SKU: HY-14769B
Availability: PreOrder

(Synonyms: 5,10-Methylenetetrafolate sodium; ANX-510 sodium)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Folitixorin sodium (5,10-Methylenetetrafolate sodium; ANX-510 sodium) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin sodium acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin sodium in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin sodium is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer.

For research use only. We do not sell to patients.

CAS No.: 133978-76-4
Formula: C₂₀H₂₁N₇Na₂O₆
Molecular Weight:501.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Folitixorin sodium Chemical Structure

CAS No.: 133978-76-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
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Biological Activity

Description

In Vitro

Folitixorin (1000 ns) sodium forms structurally conserved stable complexes with human thymidylate synthase and Klebsiella pneumoniae thymidylate synthase ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Folitixorin (0.6 mg/mouse; i.p.; once daily for five consecutive days) sodium in combination with 5‑Fluorouracil and αVEGF reduces tumor volume and improves survival rate in a colorectal tumor model of nude mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6-8 week old nude mice (nu/nu) with 2 x 10⁶ HT-29 cells^[3]
Dosage:

0.6 mg/mouse/drug ( 5-FU, Leucovorin, and αVEGF)
Administration:

i.p., daily, five consecutive days with the exception of αVEGF, dosed once (100 μg/mouse) on day 1
Result:

Reduced tumor volume and improved survival rate in a colorectal tumor model of nude mice.

Chemical Information

CAS No. 133978-76-4
Molecular Weight 501.40
Formula C₂₀H₂₁N₇Na₂O₆
SMILES

O=C1C2=C(NC(N)=N1)NCC3N2CN(C4=CC=C(C=C4)C(N[C@H](C(O[Na])=O)CCC(O[Na])=O)=O)C3
Synonyms

5,10-Methylenetetrafolate sodium; ANX-510 sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Nat Commun

Nuclear localization of MTHFD2 is required for correct mitosis progression. [Abstract]

2024 Nov 12;15(1):9529. PMID: 39532843
bioRxiv

2023 Jun 1.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shirasaka T, et al. Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo. Cancer chemotherapy and pharmacology. 1993;32(3):167-72.

[2]. Chen YL, et al. Artificial intelligence-guided discovery of a lead compound with antifolate-like activity against bacterial and human thymidylate synthases. Frontiers in cellular and infection microbiology. 2026;16:1816809. [Content Brief]

[3]. M. J. Cantwell et al. Antitumor activity of combination 5,10-methylenetetrahydrofolate, 5-fluorouracil, and anti-vascular endothelial growth factor against human colorectal HT-29 tumors in nude mice. J Clin Oncol 22, 3768-3768(2004).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Folitixorin sodium

2 Cited Publications

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Purity & Documentation
References

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Folitixorin sodium

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