133978-76-4
Chemical Structure
Folitixorin sodium
Synonym(s): 5,10-Methylenetetrafolate sodium; ANX-510 sodium
- CAS No.: 133978-76-4
- Formula:C20H21N7Na2O6
- Molecular Weight:501.40
IUPAC Name: sodium (4-(3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl)-L-glutamate
InChIKey: DIAFTFLDTRCVOX-RIWFDJIXSA-L
SMILES: O=C1C2=C(NC(N)=N1)NCC3N2CN(C4=CC=C(C=C4)C(N[C@H](C(O[Na])=O)CCC(O[Na])=O)=O)C3
Biological Activity: Folitixorin sodium (5,10-Methylenetetrafolate sodium; ANX-510 sodium) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin sodium acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin sodium in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin sodium is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer[1][2][3].
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Folitixorin sodium | Folitixorin sodium (5,10-Methylenetetrafolate sodium; ANX-510 sodium) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase. Folitixorin sodium acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin sodium in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin sodium is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer. | |||||||||||||||||||||
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References
- [1]. Shirasaka T, et al. Metabolic basis of the synergistic antitumor activities of 5-fluorouracil and cisplatin in rodent tumor models in vivo. Cancer chemotherapy and pharmacology. 1993;32(3):167-72.
- [2]. Chen YL, et al. Artificial intelligence-guided discovery of a lead compound with antifolate-like activity against bacterial and human thymidylate synthases. Frontiers in cellular and infection microbiology. 2026;16:1816809. [Content Brief]
- [3]. M. J. Cantwell et al. Antitumor activity of combination 5,10-methylenetetrahydrofolate, 5-fluorouracil, and anti-vascular endothelial growth factor against human colorectal HT-29 tumors in nude mice. J Clin Oncol 22, 3768-3768(2004).
