3432-99-3
3432-99-3
Chemical Structure
Folitixorin
Synonym(s): 5,10-Methylenetetrafolate; ANX-510 free acid
- CAS No.: 3432-99-3
- Formula:C20H23N7O6
- Molecular Weight:457.44
IUPAC Name: (4-(3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl)-L-glutamic acid
InChIKey: QYNUQALWYRSVHF-ABLWVSNPSA-N
SMILES: O=C1C2=C(NCC3N2CN(C4=CC=C(C(N[C@]([H])(C(O)=O)CCC(O)=O)=O)C=C4)C3)NC(N)=N1
Biological Activity: Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Folitixorin | 80.59% | Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research. | ||||||||||||||||||||
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Folitixorin-d4 | Folitixorin-d4 (5,10-Methylenetetrafolate-d4; ANX-510 (free acid)-d4) is the deuterium labeled Folitixorin (HY-14769). Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research. | |||||||||||||||||||||
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References
- [1]. Costantini CL, et al. Resection of hepatic metastasis after 5-fluorouracil and cofactor for colon cancer. Hepatogastroenterology. 2009;56(91-92):645-649. [Content Brief]
- [2]. Carlsson G, et al. 5-fluorouracil (5-FU) and 5,10-methylene tetrahydrofolate (5,10-CH2FH4) as adjuvant therapy in an experimental rodent colon carcinoma model. Anticancer Res. 1997;17(5A):3671-3674. [Content Brief]
Keywords
