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LY 345899 

Cat. No.: HY-101943 Purity: 98.55%
Handling Instructions

LY 345899 est un analogue du folate et est une méthylène tétrahydrofolate déshydrogénase (MTHFD1; DC301) et MTHFD2 avec un < b>IC50 de valeurs de 96 nM et 663 nM, respectivement et un Ki de 18 nM pour MTHFD1.

LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1.

For research use only. We do not sell to patients.

LY 345899 Chemical Structure

LY 345899 Chemical Structure

CAS No. : 10538-99-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1[1][2][3].

IC50 & Target

Ki: 18 nM (MTHFD1)[1]; IC50: 96 nM (MTHFD1) and 663 nM (MTHFD2)[3]

In Vitro

LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria[4].
LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SW620 or PDX-based BABL/c nude colorectal cancer (CRC) model[4]
Dosage: 5-10 mg/kg
Administration: Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks
Result: Displayed lower cell proliferation indices and higher cell apoptosis.
Exhibited no statistically significant weight loss or other signs of acute or delayed toxicity in mice.
Molecular Weight

471.42

Formula

C₂₀H₂₁N₇O₇

CAS No.

10538-99-5

SMILES

O=C(O)[[email protected]@H](NC(C1=CC=C(N2C(N3C4=C(NC(N)=NC4=O)NCC3C2)=O)C=C1)=O)CCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (265.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1213 mL 10.6063 mL 21.2125 mL
5 mM 0.4243 mL 2.1213 mL 4.2425 mL
10 mM 0.2121 mL 1.0606 mL 2.1213 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

  • 4.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (5.30 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

LY 345899LY345899LY-345899OthersInhibitorinhibitorinhibit

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Product Name:
LY 345899
Cat. No.:
HY-101943
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