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LY 345899 

Cat. No.: HY-101943 Purity: 98.55%
Handling Instructions

LY 345899 is a human cytosolic methylenetetrahydrofolate dehydrogenase/cyclohydrolase (DC301) inhibitor, with a Ki of 0.018 μM.

For research use only. We do not sell to patients.

LY 345899 Chemical Structure

LY 345899 Chemical Structure

CAS No. : 10538-99-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

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  • References

Description

LY 345899 is a human cytosolic methylenetetrahydrofolate dehydrogenase/cyclohydrolase (DC301) inhibitor, with a Ki of 0.018 μM.

IC50 & Target

Ki: 0.018 μM (DC301)[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (265.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1213 mL 10.6063 mL 21.2125 mL
5 mM 0.4243 mL 2.1213 mL 4.2425 mL
10 mM 0.2121 mL 1.0606 mL 2.1213 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

471.42

Formula

C₂₀H₂₁N₇O₇

CAS No.

10538-99-5

SMILES

O=C(O)[[email protected]@H](NC(C1=CC=C(N2C(N3C4=C(NC(N)=NC4=O)NCC3C2)=O)C=C1)=O)CCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
LY 345899
Cat. No.:
HY-101943
Quantity:

LY 345899

Cat. No.: HY-101943