2. Anti-infection
  3. Dengue Virus Flavivirus Antibiotic
  4. GAK inhibitor 2

GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV).

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GAK inhibitor 2

GAK inhibitor 2 Estructura química

No. CAS : 2396706-31-1

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg   Obtener un presupuesto  
200 mg   Obtener un presupuesto  

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GAK inhibitor 2 Related Antibodies

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Descripciòn

GAK inhibitor 2 (Compound 14g) is a potent cyclin G-associated kinase (GAK) inhibitor with an IC50 of 0.024 μM. GAK inhibitor 2 shows antiviral activity with an EC50 of 1.049 μM against dengue virus (DENV)[1].

IC50 & Target

IC50: 0.024 μM (GAK)[1]
Cellular Effect
Cell Line Type Value Description References
Huh-7 CC50
> 10 μM
Compound: 14g
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue reagent based cell viability assay
Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue reagent based cell viability assay
[PMID: 31757682]
Huh-7 EC50
1.049 μM
Compound: 14g
Antiviral activity against Dengue virus 2 infected in human HuH7 cells incubated for 48 hrs by luciferase reporter gene assay
Antiviral activity against Dengue virus 2 infected in human HuH7 cells incubated for 48 hrs by luciferase reporter gene assay
[PMID: 31757682]
Huh7.5.1 CC50
> 10 μM
Compound: 86
Cytotoxicity against human Huh-7.5.1 cells
Cytotoxicity against human Huh-7.5.1 cells
[PMID: 33539089]
Peso molecular

385.48

Fòrmula

C20H23N3O3S
No. CAS
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C(C2=NC3=C(N4C[C@@H](C)O[C@@H](C)C4)SN=C3C=C2)C=C1OC
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 33.33 mg/mL (86.46 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5942 mL 12.9708 mL 25.9417 mL
5 mM 0.5188 mL 2.5942 mL 5.1883 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.49 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5942 mL 12.9708 mL 25.9417 mL 64.8542 mL
5 mM 0.5188 mL 2.5942 mL 5.1883 mL 12.9708 mL
10 mM 0.2594 mL 1.2971 mL 2.5942 mL 6.4854 mL
15 mM 0.1729 mL 0.8647 mL 1.7294 mL 4.3236 mL
20 mM 0.1297 mL 0.6485 mL 1.2971 mL 3.2427 mL
25 mM 0.1038 mL 0.5188 mL 1.0377 mL 2.5942 mL
30 mM 0.0865 mL 0.4324 mL 0.8647 mL 2.1618 mL
40 mM 0.0649 mL 0.3243 mL 0.6485 mL 1.6214 mL
50 mM 0.0519 mL 0.2594 mL 0.5188 mL 1.2971 mL
60 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0809 mL
80 mM 0.0324 mL 0.1621 mL 0.3243 mL 0.8107 mL
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GAK inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GAK inhibitor 22396706-31-1GAK inhibitor2GAK inhibitor-2Dengue VirusFlavivirusAntibioticDENVantiviraldengue virusInhibitorinhibitorinhibit

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Nombre del producto:
GAK inhibitor 2
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