HSP90-IN-12

Art. -Nr.: HY-147747: Data Sheet Handling Instructions
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Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.

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HSP90-IN-12 Chemische Struktur

CAS. Nr. : 2408643-60-5

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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle HSP Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.89 3 Compound: 4; VAC	Antiproliferative activity against human A431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
A-431	IC₅₀	0.89 3 Compound: 4; VAC	Antiproliferative activity against human A431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
A549	IC₅₀	4.4 3 Compound: 4; VAC	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
A549	IC₅₀	4.4 3 Compound: 4; VAC	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
HT-1080	IC₅₀	1.2 3 Compound: 4; VAC	Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
HT-1080	IC₅₀	1.2 3 Compound: 4; VAC	Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
HT-29	IC₅₀	2 3 Compound: 4; VAC	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
HT-29	IC₅₀	2 3 Compound: 4; VAC	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
MCF7	IC₅₀	3.5 3 Compound: 4; VAC	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
MCF7	IC₅₀	3.5 3 Compound: 4; VAC	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
NEC8	IC₅₀	3 3 Compound: 4; VAC	Antiproliferative activity against human NEC8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NEC8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
NEC8	IC₅₀	3 3 Compound: 4; VAC	Antiproliferative activity against human NEC8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NEC8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
PANC-1	IC₅₀	3.5 3 Compound: 4; VAC	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
PANC-1	IC₅₀	3.5 3 Compound: 4; VAC	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
PC-3	IC₅₀	4.3 3 Compound: 4; VAC	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
SK-MEL-28	IC₅₀	0.97 3 Compound: 4; VAC	Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
PC-3	IC₅₀	4.3 3 Compound: 4; VAC	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
SK-MEL-28	IC₅₀	0.97 3 Compound: 4; VAC	Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]

Molekulargewicht

400.55

Formel

C₂₅H₃₆O₄

CAS. Nr.

2408643-60-5

SMILES

C/C(C)=C\CC[C@@]1(/C=C/[C@H]([C@@]2(O[C@@H]2CCC(C(C1)=O)=C)C)OC(/C=C(C)/C)=O)C

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Miura K,et al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253. [Content Brief]

HSP90-IN-12 Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP90-IN-122408643-60-5HSPHeat shock proteinsInhibitorinhibitorinhibit

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HSP90-IN-12

HSP90-IN-12 Related Antibodies

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle HSP Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

HSP90-IN-12 Related Classifications

Molaritätsrechner

Verdünnungsrechner