2408643-60-5
Chemical Structure
HSP90-IN-12
- CAS No.: 2408643-60-5
- Formula:C25H36O4
- Molecular Weight:400.55
IUPAC Name: (1R,2R,5S,11R,E)-1,5-dimethyl-8-methylene-5-(4-methylpent-3-en-1-yl)-7-oxo-12-oxabicyclo[9.1.0]dodec-3-en-2-yl 3-methylbut-2-enoate
InChIKey: MNRDTUSOZNXFSE-OCVBQOCNSA-N
SMILES: C/C(C)=C\CC[C@@]1(/C=C/[C@H]([C@@]2(O[C@@H]2CCC(C(C1)=O)=C)C)OC(/C=C(C)/C)=O)C
Biological Activity: Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.
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HSP90-IN-12 | Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro. | |||||||||||||||||||||
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