country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-147747

Copy Link Print Information

HSP90-IN-12

Among vibsanin a analogues, vibsanin a analog C (VAC) showed anti proliferative effect on various cancer cell lines, and the anti proliferative activity was the strongest among vibsanin a analogues. In addition, VAC fluctuated the amount of hsp90 related proteins in cells and inhibited hsp90 mediated protein refolding of luciferase in vitro.

For research use only. We do not sell to patients.

CAS No.: 2408643-60-5
Formula: C₂₅H₃₆O₄
Molecular Weight:400.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

HSP90-IN-12 Chemical Structure

CAS No.: 2408643-60-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All HSP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.89 μM Compound: 4; VAC	Antiproliferative activity against human A431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
A549	IC₅₀	4.4 μM Compound: 4; VAC	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
HT-1080	IC₅₀	1.2 μM Compound: 4; VAC	Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
HT-29	IC₅₀	2 μM Compound: 4; VAC	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
MCF7	IC₅₀	3.5 μM Compound: 4; VAC	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
NEC8	IC₅₀	3 μM Compound: 4; VAC	Antiproliferative activity against human NEC8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human NEC8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
PANC-1	IC₅₀	3.5 μM Compound: 4; VAC	Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
PC-3	IC₅₀	4.3 μM Compound: 4; VAC	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]
SK-MEL-28	IC₅₀	0.97 μM Compound: 4; VAC	Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 31859027]

Chemical Information

CAS No. 2408643-60-5
Molecular Weight 400.55
Formula C₂₅H₃₆O₄
SMILES

C/C(C)=C\CC[C@@]1(/C=C/[C@H]([C@@]2(O[C@@H]2CCC(C(C1)=O)=C)C)OC(/C=C(C)/C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miura K,et al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

HSP90-IN-12

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HSP90-IN-12 Related Classifications

HY-147747 Related Classifications