2. Others Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE) Environmental Pollutants
  4. ICI-63197

ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with Ki values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects.

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ICI-63197

ICI-63197 Chemical Structure

CAS No. : 27277-00-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO En stock
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Other Forms of ICI-63197:

ICI-63197 Related Antibodies

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Voir tous les produits spécifiques à Isoform Phosphodiesterase (PDE):

Voir toutes les isoformes
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with Ki values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects[1][2].

IC50 & Target[1]

PDE3/PDE Ⅲ

9 μM (Ki)

PDE Ⅳ

10 μM (Ki)

PDE Ⅰ

487 μM (Ki)

PDE Ⅱ

>1000 μM (Ki)

In Vitro

In rabbit isolated pulmonary artery previously incubated with [3H]-noradrenaline, ICI-63197 (30 μM) significantly enhances the stimulation-induced outflow of radioactivity[3].
At a stimulation frequency of 2 Hz in mouse atria, ICI-63197 (30 μM) shows no effect on the stimulation-induced outflow[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ICI-63197 Related Antibodies
In Vivo

Thirty and ninety minutes after intraperitoneal administration, ICI 63197, 0.48-29.9 µmol/kg, dose-dependently antagonized the Reserpine induced hypothermia in mice[2].
ICI-63197 potentiates the locomotor stimulatory effect of dopamine or of the ergot dopamine agonist Lisuride administered directly into the nucleus accumbens of rats. ICI-63197 has property of enhancing central noradrenergic transmission[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

207.23

Formule

C9H13N5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(CCC)C2=NC(N)=NN2C=C1C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 175 mg/mL (844.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8256 mL 24.1278 mL 48.2556 mL
5 mM 0.9651 mL 4.8256 mL 9.6511 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8256 mL 24.1278 mL 48.2556 mL 120.6389 mL
5 mM 0.9651 mL 4.8256 mL 9.6511 mL 24.1278 mL
10 mM 0.4826 mL 2.4128 mL 4.8256 mL 12.0639 mL
15 mM 0.3217 mL 1.6085 mL 3.2170 mL 8.0426 mL
20 mM 0.2413 mL 1.2064 mL 2.4128 mL 6.0319 mL
25 mM 0.1930 mL 0.9651 mL 1.9302 mL 4.8256 mL
30 mM 0.1609 mL 0.8043 mL 1.6085 mL 4.0213 mL
40 mM 0.1206 mL 0.6032 mL 1.2064 mL 3.0160 mL
50 mM 0.0965 mL 0.4826 mL 0.9651 mL 2.4128 mL
60 mM 0.0804 mL 0.4021 mL 0.8043 mL 2.0106 mL
80 mM 0.0603 mL 0.3016 mL 0.6032 mL 1.5080 mL
100 mM 0.0483 mL 0.2413 mL 0.4826 mL 1.2064 mL
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ICI-63197 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICI-6319727277-00-5ICI63197ICI 63197Phosphodiesterase (PDE)Environmental PollutantsEnvironmental ContaminantsPDE3PDE4antidepressant effectsInhibitorinhibitorinhibit

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HY-103024
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