27277-00-5
27277-00-5
Chemical Structure
ICI-63197
- CAS No.: 27277-00-5
- Formula:C9H13N5O
- Molecular Weight:207.23
IUPAC Name: 2-amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
InChIKey: UQDVRVNMIJAGRK-UHFFFAOYSA-N
SMILES: O=C1N(CCC)C2=NC(N)=NN2C=C1C
Biological Activity: ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with Ki values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects[1][2].
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ICI-63197 | 99.14% | ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with Ki values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects. | ||||||||||||||||||||
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ICI-63197 (Standard) | ≥98% | ICI-63197 (Standard) is the analytical standard of ICI-63197 (HY-103024). This product is intended for research and analytical applications. ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with Ki values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects. | ||||||||||||||||||||
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References
- [1]. M Hoey, et al. Identification and selective inhibition of four distinct soluble forms of cyclic nucleotide phosphodiesterase activity from kidney. Biochem Pharmacol. 1990 Jul 15;40(2):193-202. [Content Brief]
- [2]. H Wachtel. Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors. Neuropharmacology. 1983 Mar;22(3):267-72. [Content Brief]
