2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Mitochondrial Metabolism Reactive Oxygen Species (ROS)
  4. Imeglimin hydrochloride

イメグリミン塩酸塩  (Synonyms: Imeglimin (hydrochloride); EMD 387008 hydrochloride)

製品番号: HY-14771A 純度: 99.98%
COA 取扱説明書 Technical Support

Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.

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Imeglimin hydrochloride

イメグリミン塩酸塩 構造式

CAS 番号 : 775351-61-6

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 107 在庫あり
Solution
10 mM * 1 mL in DMSO USD 107 在庫あり
Solid
5 mg $98 在庫あり
10 mg $155 在庫あり
25 mg $300 在庫あり
50 mg $465 在庫あり
100 mg $698 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 8 publication(s) in Google Scholar

Other Forms of Imeglimin hydrochloride:

イメグリミン塩酸塩 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].

IC50 & Target

ROS; mitochondrial function[1]
体外実験

Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

イメグリミン塩酸塩 関連抗体

Cell Viability Assay[2]

Cell Line: Human endothelial cells (HMEC-1)
Concentration: 100 μM and10 mM
Incubation Time: 100 μM for 24 h, 10 mM for 4 h
Result: Prevention of cell death.
体内実験

Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6JOlaHsd mice (4 weeks old)[1]
Dosage: 200 mg/kg
Administration: Oral gavage; b.i.d.; 6 weeks
Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
分子量

191.66

分子式

C6H14ClN5
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.NC1=N[C@@H](C)N=C(N(C)C)N1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

H2O : ≥ 50 mg/mL (260.88 mM)

DMSO : 25 mg/mL (130.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2175 mL 26.0876 mL 52.1752 mL
5 mM 1.0435 mL 5.2175 mL 10.4350 mL
10 mM 0.5218 mL 2.6088 mL 5.2175 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (10.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (10.85 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (521.75 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.98%

COA (248 KB) HNMR (237 KB) RP-HPLC (245 KB) MS (178 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.2175 mL 26.0876 mL 52.1752 mL 130.4381 mL
5 mM 1.0435 mL 5.2175 mL 10.4350 mL 26.0876 mL
10 mM 0.5218 mL 2.6088 mL 5.2175 mL 13.0438 mL
15 mM 0.3478 mL 1.7392 mL 3.4783 mL 8.6959 mL
20 mM 0.2609 mL 1.3044 mL 2.6088 mL 6.5219 mL
25 mM 0.2087 mL 1.0435 mL 2.0870 mL 5.2175 mL
30 mM 0.1739 mL 0.8696 mL 1.7392 mL 4.3479 mL
40 mM 0.1304 mL 0.6522 mL 1.3044 mL 3.2610 mL
50 mM 0.1044 mL 0.5218 mL 1.0435 mL 2.6088 mL
60 mM 0.0870 mL 0.4348 mL 0.8696 mL 2.1740 mL
80 mM 0.0652 mL 0.3261 mL 0.6522 mL 1.6305 mL
100 mM 0.0522 mL 0.2609 mL 0.5218 mL 1.3044 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Imeglimin hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Imeglimin775351-61-6EMD 387008EMD387008EMD-387008Mitochondrial MetabolismReactive Oxygen Species (ROS)oralglucoseloweringinsulinsensitivityROSmitochondrialfunctionInhibitorinhibitorinhibit

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製品名:
Imeglimin hydrochloride
製品番号:
HY-14771A
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