Imeglimin
Based on 8 publication(s) in Google Scholar
Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.
For research use only. We do not sell to patients.
- Purity: 99.10%
- CAS No.: 775351-65-0
- Formula: C6H13N5
- Molecular Weight:155.20
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Imeglimin
More- Cell Rep Med. 2025 Aug 19;6(8):102254. [Abstract]
- Diabetes. 2022 Mar 1;71(3):424-439. [Abstract]
- Mol Neurobiol. 2022 May;59(5):2977-2991. [Abstract]
- Endocrinology. 2023 Jun 26;164(8):bqad095. [Abstract]
- Cancer Med. 2026 Mar;15(3):e71651. [Abstract]
- FEBS Lett. 2025 Sep 15. [Abstract]
- J Diabetes Investig. 2025 Jun 13. [Abstract]
- J Pharmacol Sci. 2025 Dec;159(4):301-309. [Abstract]
Biological Activity
ROS; mitochondrial function[1]
Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) fully prevents tert-butylhydroperoxide (tBH)-induced cell death[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human endothelial cells (HMEC-1)
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Concentration:100 μM and10 mM
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Incubation Time:100 μM for 24 h, 10 mM for 4 h
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Result:Prevention of cell death.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6JOlaHsd mice (4 weeks old)[1]
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Dosage:200 mg/kg
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Administration:Oral gavage; b.i.d.; 6 weeks
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Result:A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 775351-65-0
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Appearance Solid
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Molecular Weight 155.20
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Formula C6H13N5
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Color White to off-white
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SMILES
NC1=N[C@@H](C)N=C(N(C)C)N1
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Synonyms
EMD 387008
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
2025 Aug 19;6(8):102254. PMID: 40713970 -
Diabetes
Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway. [Abstract]2022 Mar 1;71(3):424-439. PMID: 34588186 -
Mol Neurobiol
Imeglimin Is Neuroprotective Against Ischemic Brain Injury in Rats-a Study Evaluating Neuroinflammation and Mitochondrial Functions. [Abstract]2022 May;59(5):2977-2991. PMID: 35257284 -
Endocrinology
Protective effects of imeglimin and metformin combination therapy on β-cells in db/db male mice. [Abstract]2023 Jun 26;164(8):bqad095. PMID: 37314160 -
Cancer Med
Imeglimin Exerts Anti-Tumor Activity in Multiple Myeloma Through Affecting Energy Metabolism and Downregulating IL-16 Expression. [Abstract]2026 Mar;15(3):e71651. PMID: 41782019 -
FEBS Lett
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells. [Abstract]2025 Sep 15. PMID: 40948113 -
J Diabetes Investig
Imeglimin improves hyperglycemia and hypoglycemia-induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells. [Abstract]2025 Jun 13. PMID: 40509800 -
J Pharmacol Sci
Effects of imeglimin on mitochondrial functions and ischemic brain damage in young and aging rats. [Abstract]2025 Dec;159(4):301-309. PMID: 41241441
Solvent & Solubility
DMSO : 32 mg/mL (206.19 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 3.2 mg/mL (20.62 mM); Clear solution
This protocol yields a clear solution of ≥ 3.2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 3.2 mg/mL (20.62 mM); Clear solution
This protocol yields a clear solution of ≥ 3.2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (32.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64. [Content Brief]
[2]. Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 6.4433 mL | 32.2165 mL | 64.4330 mL | 161.0825 mL |
| 5 mM | 1.2887 mL | 6.4433 mL | 12.8866 mL | 32.2165 mL | |
| 10 mM | 0.6443 mL | 3.2216 mL | 6.4433 mL | 16.1082 mL | |
| 15 mM | 0.4296 mL | 2.1478 mL | 4.2955 mL | 10.7388 mL | |
| 20 mM | 0.3222 mL | 1.6108 mL | 3.2216 mL | 8.0541 mL | |
| 25 mM | 0.2577 mL | 1.2887 mL | 2.5773 mL | 6.4433 mL | |
| 30 mM | 0.2148 mL | 1.0739 mL | 2.1478 mL | 5.3694 mL | |
| 40 mM | 0.1611 mL | 0.8054 mL | 1.6108 mL | 4.0271 mL | |
| 50 mM | 0.1289 mL | 0.6443 mL | 1.2887 mL | 3.2216 mL | |
| 60 mM | 0.1074 mL | 0.5369 mL | 1.0739 mL | 2.6847 mL | |
| 80 mM | 0.0805 mL | 0.4027 mL | 0.8054 mL | 2.0135 mL | |
| 100 mM | 0.0644 mL | 0.3222 mL | 0.6443 mL | 1.6108 mL |
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