Imeglimin hydrochloride
Based on 9 publication(s) in Google Scholar
Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.
For research use only. We do not sell to patients.
- Purity: 99.98%
- CAS No.: 775351-61-6
- Formula: C6H14ClN5
- Molecular Weight:191.66
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Imeglimin hydrochloride
More- J Clin Invest. 2026 Apr 2;136(12):e196112. [Abstract]
- Cell Rep Med. 2025 Aug 19;6(8):102254. [Abstract]
- Diabetes. 2022 Mar 1;71(3):424-439. [Abstract]
- Mol Neurobiol. 2022 May;59(5):2977-2991. [Abstract]
- Endocrinology. 2023 Jun 26;164(8):bqad095. [Abstract]
- J Diabetes Investig. 2025 Jun 13. [Abstract]
- Cancer Med. 2026 Mar;15(3):e71651. [Abstract]
- FEBS Lett. 2025 Sep 15. [Abstract]
- J Pharmacol Sci. 2025 Dec;159(4):301-309. [Abstract]
Biological Activity
ROS; mitochondrial function[1]
Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human endothelial cells (HMEC-1)
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Concentration:100 μM and10 mM
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Incubation Time:100 μM for 24 h, 10 mM for 4 h
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Result:Prevention of cell death.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6JOlaHsd mice (4 weeks old)[1]
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Dosage:200 mg/kg
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Administration:Oral gavage; b.i.d.; 6 weeks
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Result:A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
Chemical Information
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CAS No. 775351-61-6
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Appearance Solid
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Molecular Weight 191.66
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Formula C6H14ClN5
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Color White to off-white
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SMILES
[H]Cl.NC1=N[C@@H](C)N=C(N(C)C)N1
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Synonyms
EMD 387008 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (9)
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Journal Impact Factor
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Most Recent
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J Clin Invest
Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury. [Abstract]2026 Apr 2;136(12):e196112. PMID: 41926211 -
Cell Rep Med
2025 Aug 19;6(8):102254. PMID: 40713970 -
Diabetes
Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway. [Abstract]2022 Mar 1;71(3):424-439. PMID: 34588186 -
Mol Neurobiol
Imeglimin Is Neuroprotective Against Ischemic Brain Injury in Rats-a Study Evaluating Neuroinflammation and Mitochondrial Functions. [Abstract]2022 May;59(5):2977-2991. PMID: 35257284 -
Endocrinology
Protective effects of imeglimin and metformin combination therapy on β-cells in db/db male mice. [Abstract]2023 Jun 26;164(8):bqad095. PMID: 37314160 -
J Diabetes Investig
Imeglimin improves hyperglycemia and hypoglycemia-induced cell death and mitochondrial dysfunction in immortalized adult mouse Schwann IMS32 cells. [Abstract]2025 Jun 13. PMID: 40509800 -
Cancer Med
Imeglimin Exerts Anti-Tumor Activity in Multiple Myeloma Through Affecting Energy Metabolism and Downregulating IL-16 Expression. [Abstract]2026 Mar;15(3):e71651. PMID: 41782019 -
FEBS Lett
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells. [Abstract]2025 Sep 15. PMID: 40948113 -
J Pharmacol Sci
Effects of imeglimin on mitochondrial functions and ischemic brain damage in young and aging rats. [Abstract]2025 Dec;159(4):301-309. PMID: 41241441
Solvent & Solubility
H2O : ≥ 50 mg/mL (260.88 mM)
DMSO : 25 mg/mL (130.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (10.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (10.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (521.75 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64. [Content Brief]
[2]. Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 5.2175 mL | 26.0876 mL | 52.1752 mL | 130.4381 mL |
| 5 mM | 1.0435 mL | 5.2175 mL | 10.4350 mL | 26.0876 mL | |
| 10 mM | 0.5218 mL | 2.6088 mL | 5.2175 mL | 13.0438 mL | |
| 15 mM | 0.3478 mL | 1.7392 mL | 3.4783 mL | 8.6959 mL | |
| 20 mM | 0.2609 mL | 1.3044 mL | 2.6088 mL | 6.5219 mL | |
| 25 mM | 0.2087 mL | 1.0435 mL | 2.0870 mL | 5.2175 mL | |
| 30 mM | 0.1739 mL | 0.8696 mL | 1.7392 mL | 4.3479 mL | |
| 40 mM | 0.1304 mL | 0.6522 mL | 1.3044 mL | 3.2610 mL | |
| 50 mM | 0.1044 mL | 0.5218 mL | 1.0435 mL | 2.6088 mL | |
| 60 mM | 0.0870 mL | 0.4348 mL | 0.8696 mL | 2.1740 mL | |
| 80 mM | 0.0652 mL | 0.3261 mL | 0.6522 mL | 1.6305 mL | |
| 100 mM | 0.0522 mL | 0.2609 mL | 0.5218 mL | 1.3044 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Imeglimin hydrochloride Related Classifications
HY-14771A Related Classifications
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