1. Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
  2. Mitochondrial Metabolism
    Reactive Oxygen Species
  3. Imeglimin hydrochloride

Imeglimin hydrochloride (Synonyms: EMD 387008 hydrochloride)

Cat. No.: HY-14771A Purity: >98.0%
Handling Instructions

Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function.

For research use only. We do not sell to patients.

Imeglimin hydrochloride Chemical Structure

Imeglimin hydrochloride Chemical Structure

CAS No. : 775351-61-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 456 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].

IC50 & Target

ROS; mitochondrial function[1]

In Vitro

Preincubation with Imeglimin (10 mM for 4 h or 100 μM for 24 h) also fully prevented tert-butylhydroperoxide (tBH)-induced cell death[2].

Cell Viability Assay[2]

Cell Line: Human endothelial cells (HMEC-1)
Concentration: 100 μM and10 mM
Incubation Time: 100 μM for 24 h, 10 mM for 4 h
Result: Prevention of cell death.
In Vivo

Imeglimin (200 mg/kg b.i.d. by oral gavage during the last 6 weeks of HFHSD feeding) significantly decreases hyperglycemia, and restores normal glucose tolerance[1].

Animal Model: Male C57BL/6JOlaHsd mice (4 weeks old)[1]
Dosage: 200 mg/kg
Administration: Oral gavage; b.i.d.; 6 weeks
Result: A slight decrease in body weight and food intake associated with some diarrhea was observed but only during the first few days of treatment.
Clinical Trial
Molecular Weight

191.66

Formula

C₆H₁₄ClN₅

CAS No.

775351-61-6

SMILES

[H]Cl.NC1=N[[email protected]@H](C)N=C(N(C)C)N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (130.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2176 mL 26.0879 mL 52.1757 mL
5 mM 1.0435 mL 5.2176 mL 10.4351 mL
10 mM 0.5218 mL 2.6088 mL 5.2176 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (13.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (13.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (13.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

ImegliminEMD 387008EMD387008EMD-387008Mitochondrial MetabolismReactive Oxygen SpeciesoralglucoseloweringinsulinsensitivityROSmitochondrialfunctionInhibitorinhibitorinhibit

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Product Name:
Imeglimin hydrochloride
Cat. No.:
HY-14771A
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