Kdo2-Lipid A ammonium

Name: Kdo2-Lipid A ammonium
Brand: MedChemExpress
SKU: HY-N8277
Rating: 5.0 (3 reviews)

製品番号: HY-N8277 純度: 95.2%: Data Sheet SDS COA 取扱説明書
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Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxin activity equal to LPS. Kdo2-Lipid A ammonium is highly selective for TLR4. Kdo2-Lipid A ammonium stimulates the release of both TNF and PGE2.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Kdo2-Lipid A ammonium 構造式

CAS 番号 : 1246298-62-3

容量	価格（税別）	在庫状況	数量
1 mg	$890	在庫あり	Estimated Time of Arrival: December 31
5 mg		お問い合わせ
10 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Other Forms of Kdo2-Lipid A ammonium:

Kdo2-Lipid A お問い合わせ

顧客検証

Toll-like Receptor (TLR) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

TNF Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

TLR4

体外実験

Kdo2-Lipid A (1 μM) stimulates the release of both TNF and PGE2 from the adult rat spinal astrocytes cell cultures^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	TNF and PGE2
Concentration:	1 µM
Incubation Time:
Result:	Amounts of protein (mg) is 6.2 ± 0.6 ng/mL and 1.4 ± 0.3 ng/mL for TNF and PGE2.

体内実験

KDO2-Lipid A (i.t.) activates toll-like receptor 4 (TLR4) in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats (Male Holzman Sprague-Dawley, 300–400 g) ^[1]
Dosage:	0.1 to 10 µg
Administration:	I.T.; 0.1-10 µg; prior and 15, 30, 60, 90 and 120 min after injection of Kdo2-Lipid A.
Result:	Intrathecal injection of 1 µg Kdo2-Lipid A induces allodynia, and the animals appeared to be sick after i.t. injection of Kdo2-Lipid A.

臨床実験

分子量

2306.84

分子式

C₁₁₀H₂₁₄N₆O₃₉P₂

CAS 番号

1246298-62-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(C[C@@H](CC)OC(CC)=O)O[C@@H]([C@@H]([C@H]1CO[C@](C[C@H]([C@@H]2O)O[C@@](O[C@]([C@H]3O)([H])[C@H](O)CO)(C[C@H]3O)C(O)=O)(O[C@]2([H])[C@H](O)CO)C(O)=O)O[P](O)(O)=O)[C@H]([C@@H](O1)OC[C@@H](O[C@@H]4O[P](O)(O)=O)[C@H]([C@@H]([C@H]4NC(C[C@H](O)CC)=O)OC(C[C@H](O)CC)=O)O)NC(C[C@@H](CCC)OC(CC)=O)=O.N.N.N.[10].[12].[9].[10].[10].[10].N

Structure Classification

Others

Initial Source

Microorganisms

E. coli

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

純度とドキュメンテーション

純度: ≥99.0%

Select Batch:

データシート (287 KB) SDS (252 KB)

COA (275 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Saito O, et al. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. Br J Pharmacol. 2010;160(7):1754-1764. [Content Brief]