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  4. L-Ascorbic acid 2-phosphate

L-Ascorbic acid 2-phosphate  (Synonyms: 2-Phospho-L-ascorbic acid; LAA2P)

製品番号: HY-103701
COA 取扱説明書 Technical Support

L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.

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L-Ascorbic acid 2-phosphate

L-Ascorbic acid 2-phosphate 構造式

CAS 番号 : 23313-12-4

容量 価格（税別） 在庫状況 数量
100 mg $30 在庫あり
500 mg $50 在庫あり
1 g $60 在庫あり
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Based on 10 publication(s) in Google Scholar

Other Forms of L-Ascorbic acid 2-phosphate:

L-Ascorbic acid 2-phosphate 関連抗体

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製品説明

L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) is a long-acting vitamin C derivative that can stimulate collagen formation and expression[1]. L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外実験

L-Ascorbic acid 2-phosphate (0.1-1.5 mM; 2 to 3 weeks with medium exchange every 2 to 3 days) significantly stimulates cell growth, whereas addition of l-Ascorbic acid (Asc) achieves only weak growth stimulation. A combination of Asc-2P and bFGF significantly increases cell growth, but supplementation with EGF and/or insulin does not have any additional effect [1].
L-Ascorbic acid 2-phosphate (50 μM-250 μM) is needed for the effective osteogenic differentiation of human adipose stem cells (hASCs), and higher concentrations of AsA2-P results in increased runx2 expression and ALP activity. The highest proliferation, ALP activity and runx2 expression is achieved with 150 μM AsA2-P and 10 nM dexamethasone (Dex), and 250 μM AsA2-P and 5 nM Dex[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ascorbic acid 2-phosphate 関連抗体

Cell Proliferation Assay[1]

Cell Line: Human corneal endothelial cells (HCECs) 
Concentration: 0.1 mM; 0.3 mM; 1.5 mM
Incubation Time: 2 to 3 weeks with medium exchange every 2 to 3 days
Result: Stimulated HCEC cells growth.
分子量

256.10

分子式

C6H9O9P
CAS 番号
Appearance

Solid

Color

Off-white to yellow

SMILES

OC([C@H](O1)[C@H](CO)O)=C(OP(O)(O)=O)C1=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外: 

1 M HCl : 25 mg/mL (97.62 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9047 mL 19.5236 mL 39.0472 mL
5 mM 0.7809 mL 3.9047 mL 7.8094 mL
10 mM 0.3905 mL 1.9524 mL 3.9047 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション

COA (250 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1 M HCl 1 mM 3.9047 mL 19.5236 mL 39.0472 mL 97.6181 mL
5 mM 0.7809 mL 3.9047 mL 7.8094 mL 19.5236 mL
10 mM 0.3905 mL 1.9524 mL 3.9047 mL 9.7618 mL
15 mM 0.2603 mL 1.3016 mL 2.6031 mL 6.5079 mL
20 mM 0.1952 mL 0.9762 mL 1.9524 mL 4.8809 mL
25 mM 0.1562 mL 0.7809 mL 1.5619 mL 3.9047 mL
30 mM 0.1302 mL 0.6508 mL 1.3016 mL 3.2539 mL
40 mM 0.0976 mL 0.4881 mL 0.9762 mL 2.4405 mL
50 mM 0.0781 mL 0.3905 mL 0.7809 mL 1.9524 mL
60 mM 0.0651 mL 0.3254 mL 0.6508 mL 1.6270 mL
80 mM 0.0488 mL 0.2440 mL 0.4881 mL 1.2202 mL
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L-Ascorbic acid 2-phosphate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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Keywords:

L-Ascorbic acid 2-phosphate23313-12-42-Phospho-L-ascorbic acid LAA2PPhosphataseReactive Oxygen Species (ROS)Endogenous MetabolitehASCosteogenicdifferentiationmediumsupplementrunx2AvitaminCderivativeInhibitorinhibitorinhibit

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