2. Academic Validation
  3. The actin cytoskeleton is important for pseudorabies virus infection

The actin cytoskeleton is important for pseudorabies virus infection

  • Virology. 2024 Dec:600:110233. doi: 10.1016/j.virol.2024.110233.
Xin-Man Li 1,  Kun Xu 1,  Jin-Yuan Wang 1,  Jie-Yuan Guo 1,  Xiao-Han Wang 1,  Lei Zeng 1,  Bo Wan 2,  Jiang Wang 3,  Bei-Bei Chu 3,  Guo-Yu Yang 4,  Jia-Jia Pan 5,  Wen-Bo Hao 6
Affiliations

Affiliations

  • 1 College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, China; Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Zhengzhou, 450046, China; Key Laboratory of Veterinary Biotechnology of Henan Province, Zhengzhou, 450046, China.
  • 2 College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, China; Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Zhengzhou, 450046, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, China.
  • 3 College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, China; Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Zhengzhou, 450046, China; Key Laboratory of Veterinary Biotechnology of Henan Province, Zhengzhou, 450046, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, China.
  • 4 Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Zhengzhou, 450046, China; Key Laboratory of Veterinary Biotechnology of Henan Province, Zhengzhou, 450046, China; Henan University of Animal Husbandry and Economy, Zhengzhou, 450047, China.
  • 5 College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, China; Key Laboratory of Animal Biochemistry and Nutrition, Ministry of Agriculture and Rural Affairs of the People's Republic of China, Zhengzhou, 450046, China; Key Laboratory of Veterinary Biotechnology of Henan Province, Zhengzhou, 450046, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Zhengzhou 450046, China. Electronic address: [email protected].
  • 6 College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450046, China. Electronic address: [email protected].
PMID: 39255726 DOI: 10.1016/j.virol.2024.110233
Abstract

Viruses are dependent on the host factors for their replication and survival. Therefore, identification of host factors that druggable for Antiviral development is crucial. The actin Cytoskeleton plays an important role in the virus Infection. The dynamics change of actin and its function are regulated by multiple actin-associated proteins (AAPs). However, the role and mechanism of various AAPs in the life cycle of virus are still enigmatic. In this study, we analyzed the roles of actin and AAPs in the replication of pseudorabies virus (PRV). Using a library of compounds targeting AAPs, our data found that multiple AAPs, such as Rho-GTPases, ROCK, Myosin and Formin were involved in PRV Infection. Besides, our result demonstrated that the actin-binding protein Drebrin was also participated in PRV Infection. Further studies are necessary to elucidate the molecular mechanism of AAPs in the virus life cycle, in the hope of mining host factors for Antiviral developments.

Keywords

Actin; Actin-associated protein; Cytoskeleton; Pseudorabies virus infection.

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