2. Academic Validation
  3. Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients

Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients

  • NPJ Digit Med. 2025 Nov 17;8(1):663. doi: 10.1038/s41746-025-02029-8.
Xichun Qin # 1,  Bo Cheng # 2,  Shangshang Ma # 1,  Kun Li # 1,  Yongfei Fan 1,  Mingjun Li 1,  Rangrang Wang 1,  Xuefeng Ai 1,  Leilei Wu 3,  Xiucheng Liu 4,  Xiaojin Wu 5,  Dong Xie 6
Affiliations

Affiliations

  • 1 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China.
  • 2 Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai, 200292, China.
  • 3 Department of Thoracic Surgery, Hangzhou Institute of Medicine (HIM), Zhejiang Cancer Hospital, Chinese Academy of Sciences, Hangzhou, 310005, China. [email protected].
  • 4 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China. [email protected].
  • 5 Department of Radiation Oncology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Jiefang South Road, No. 199, Xuzhou, 221000, China. [email protected].
  • 6 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China. [email protected].
  • # Contributed equally.
PMID: 41249389 DOI: 10.1038/s41746-025-02029-8
Abstract

Emotional distress (ED), including anxiety and depression, is highly prevalent in patients with non-small cell lung Cancer (NSCLC) and may compromise both quality of life and treatment outcomes. In this study, we evaluated the mental health status of 1185 surgically treated NSCLC patients and developed a predictive model integrating clinical and demographic factors. Adjuvant therapy after lung Cancer surgery was associated with an increased risk of ED, particularly chemotherapy. To address safety concerns, we further examined commonly used anti-ED drugs in experimental models and found no evidence of tumor-promoting effects. Importantly, tandospirone not only alleviates ED but also enhances the therapeutic efficacy of cisplatin. These findings highlight the clinical importance of systematic ED management in lung Cancer care and suggest tandospirone as a promising candidate that may simultaneously support psychological well-being and improve chemotherapy response, offering a more comprehensive treatment strategy for NSCLC patients.

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