2. Cell Cycle/DNA Damage Stem Cell/Wnt MAPK/ERK Pathway NF-κB
  3. Polo-like Kinase (PLK) ERK NF-κB
  4. Nε-(Carboxymethyl)-L-lysine

Nε-(Carboxymethyl)-L-lysine  (Synonyms: CML; N6-(Carboxymethyl)-L-lysine; Nε-(1-Carboxymethyl)-L-lysine)

Cat. No.: HY-W286743 Pureza: 95.0%
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Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties.

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Nε-(Carboxymethyl)-L-lysine

Nε-(Carboxymethyl)-L-lysine Estructura química

No. CAS : 5746-04-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Nε-(Carboxymethyl)-L-lysine:

Nε-(Carboxymethyl)-L-lysine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nε-(Carboxymethyl)-L-lysine

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PLK1 PLK2 PLK3 PLK4

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Descripciòn

Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties[1][2].

IC50 & Target[1]

PLK1

 

In Vitro

Nε-(Carboxymethyl)-L-lysine (25 μg/mL; 1-3 months) induces time-dependent centrosome amplification in THLE2 and THLE3 human hepatocytes, with 8-10-fold higher CA frequencies after 3 months of treatment[1].
Nε-(Carboxymethyl)-L-lysine (25 μg/mL; 1-3 months) upregulates PLK1 and CEP20 expression in THLE2 and THLE3 human hepatocytes, which are critical mediators of CML-driven centrosome amplification[1].
Nε-(Carboxymethyl)-L-lysine (25-50 μM; 6 days) significantly enhances the invasion ability of MG63 and U2OS human osteosarcoma cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nε-(Carboxymethyl)-L-lysine Related Antibodies
In Vivo

Nε-(Carboxymethyl)-L-lysine (25 mg/kg/day; oral (dietary); daily; 12 weeks) significantly increases HCC tumor burden and centrosome amplification rates in DEN-initiated BALB/c nu/nu mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

204.22

Fòrmula

C8H16N2O4
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

C(CCNCC(=O)O)C[C@@H](C(=O)O)N
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

H2O : 35 mg/mL (171.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8967 mL 24.4834 mL 48.9668 mL
5 mM 0.9793 mL 4.8967 mL 9.7934 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.8967 mL 24.4834 mL 48.9668 mL 122.4170 mL
5 mM 0.9793 mL 4.8967 mL 9.7934 mL 24.4834 mL
10 mM 0.4897 mL 2.4483 mL 4.8967 mL 12.2417 mL
15 mM 0.3264 mL 1.6322 mL 3.2645 mL 8.1611 mL
20 mM 0.2448 mL 1.2242 mL 2.4483 mL 6.1209 mL
25 mM 0.1959 mL 0.9793 mL 1.9587 mL 4.8967 mL
30 mM 0.1632 mL 0.8161 mL 1.6322 mL 4.0806 mL
40 mM 0.1224 mL 0.6121 mL 1.2242 mL 3.0604 mL
50 mM 0.0979 mL 0.4897 mL 0.9793 mL 2.4483 mL
60 mM 0.0816 mL 0.4081 mL 0.8161 mL 2.0403 mL
80 mM 0.0612 mL 0.3060 mL 0.6121 mL 1.5302 mL
100 mM 0.0490 mL 0.2448 mL 0.4897 mL 1.2242 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nε-(Carboxymethyl)-L-lysine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nε-(Carboxymethyl)-L-lysine5746-04-3CMLN6-(Carboxymethyl)-L-lysineNε-(1-Carboxymethyl)-L-lysinePolo-like Kinase (PLK)ERKNF-κBExtracellular signal regulated kinasesNuclear factor-κBNuclear factor-kappaBAKThepatocellular carcinomaRAGEDNMT3BEGR1PLK1NFκBCEP20human hepatocytesInhibitorinhibitorinhibit

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