2. Cell Cycle/DNA Damage Stem Cell/Wnt MAPK/ERK Pathway NF-κB
  3. Polo-like Kinase (PLK) ERK NF-κB
  4. Nε-(Carboxymethyl)-L-lysine

Nε-(Carboxymethyl)-L-lysine  (Synonyms: CML; N6-(Carboxymethyl)-L-lysine; Nε-(1-Carboxymethyl)-L-lysine)

製品番号: HY-W286743 純度: 95.0%
COA 取扱説明書 Technical Support

Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties.

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Nε-(Carboxymethyl)-L-lysine

Nε-(Carboxymethyl)-L-lysine 構造式

CAS 番号 : 5746-04-3

容量 価格（税別） 在庫状況 数量
5 mg $120 在庫あり
10 mg $190 在庫あり
25 mg $400 在庫あり
50 mg $680 在庫あり
100 mg $1160 在庫あり
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Based on 1 publication(s) in Google Scholar

Other Forms of Nε-(Carboxymethyl)-L-lysine:

Nε-(Carboxymethyl)-L-lysine 関連抗体

Top Publications Citing Use of Products

Polo-like Kinase (PLK) アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
PLK1 PLK2 PLK3 PLK4

ERK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
ERK ERK1 ERK2 ERK5 ERK8

NF-κB アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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製品説明

Nε-(Carboxymethyl)-L-lysine (CML) is an orally active advanced glycation end product. Nε-(Carboxymethyl)-L-lysine upregulates the expression of PLK1 and CEP20, and induces the activation of RAGE and ERK/NFκB. Nε-(Carboxymethyl)-L-lysine drives centrosome amplification. Nε-(Carboxymethyl)-L-lysine induces malignant transformation of hepatocytes and promotes the development of hepatocellular carcinoma. Nε-(Carboxymethyl)-L-lysine induces epithelial-mesenchymal transition in osteosarcoma cells and enhances their migration and invasion properties[1][2].

IC50 & Target[1]

PLK1

 

体外実験

Nε-(Carboxymethyl)-L-lysine (25 μg/mL; 1-3 months) induces time-dependent centrosome amplification in THLE2 and THLE3 human hepatocytes, with 8-10-fold higher CA frequencies after 3 months of treatment[1].
Nε-(Carboxymethyl)-L-lysine (25 μg/mL; 1-3 months) upregulates PLK1 and CEP20 expression in THLE2 and THLE3 human hepatocytes, which are critical mediators of CML-driven centrosome amplification[1].
Nε-(Carboxymethyl)-L-lysine (25-50 μM; 6 days) significantly enhances the invasion ability of MG63 and U2OS human osteosarcoma cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nε-(Carboxymethyl)-L-lysine 関連抗体
体内実験

Nε-(Carboxymethyl)-L-lysine (25 mg/kg/day; oral (dietary); daily; 12 weeks) significantly increases HCC tumor burden and centrosome amplification rates in DEN-initiated BALB/c nu/nu mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

204.22

分子式

C8H16N2O4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

C(CCNCC(=O)O)C[C@@H](C(=O)O)N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 35 mg/mL (171.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8967 mL 24.4834 mL 48.9668 mL
5 mM 0.9793 mL 4.8967 mL 9.7934 mL
10 mM 0.4897 mL 2.4483 mL 4.8967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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一般には略語で表示されます：C1V1 = C2V2

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.8967 mL 24.4834 mL 48.9668 mL 122.4170 mL
5 mM 0.9793 mL 4.8967 mL 9.7934 mL 24.4834 mL
10 mM 0.4897 mL 2.4483 mL 4.8967 mL 12.2417 mL
15 mM 0.3264 mL 1.6322 mL 3.2645 mL 8.1611 mL
20 mM 0.2448 mL 1.2242 mL 2.4483 mL 6.1209 mL
25 mM 0.1959 mL 0.9793 mL 1.9587 mL 4.8967 mL
30 mM 0.1632 mL 0.8161 mL 1.6322 mL 4.0806 mL
40 mM 0.1224 mL 0.6121 mL 1.2242 mL 3.0604 mL
50 mM 0.0979 mL 0.4897 mL 0.9793 mL 2.4483 mL
60 mM 0.0816 mL 0.4081 mL 0.8161 mL 2.0403 mL
80 mM 0.0612 mL 0.3060 mL 0.6121 mL 1.5302 mL
100 mM 0.0490 mL 0.2448 mL 0.4897 mL 1.2242 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nε-(Carboxymethyl)-L-lysine Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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Keywords:

Nε-(Carboxymethyl)-L-lysine5746-04-3CMLN6-(Carboxymethyl)-L-lysineNε-(1-Carboxymethyl)-L-lysinePolo-like Kinase (PLK)ERKNF-κBExtracellular signal regulated kinasesNuclear factor-κBNuclear factor-kappaBAKThepatocellular carcinomaRAGEDNMT3BEGR1PLK1NFκBCEP20human hepatocytesInhibitorinhibitorinhibit

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