N1-Acetylspermidine hydrochloride

Name: N1-Acetylspermidine hydrochloride
Brand: MedChemExpress
SKU: HY-113056A
Rating: 4.5 (0 reviews)

製品番号: HY-113056A 純度: 99.13%: Data Sheet SDS COA 取扱説明書
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N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamines and a substrate for polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride can promote Apoptosis in combination with Procyanidins. N1-Acetylspermidine hydrochloride has a certain cleavage efficiency at apurinic sites of DNA. N1-Acetylspermidine hydrochloride can be used in colorectal cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

N1-Acetylspermidine hydrochloride 構造式

CAS 番号 : 34450-16-3

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 275	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$250	在庫あり	Estimated Time of Arrival: December 31
10 mg	$400	在庫あり	Estimated Time of Arrival: December 31
25 mg	$800	在庫あり	Estimated Time of Arrival: December 31
50 mg	$1280	在庫あり	Estimated Time of Arrival: December 31
100 mg	$2050	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Other Forms of N1-Acetylspermidine hydrochloride:

N1-Acetylspermidine-d₃ hydrochloride 在庫あり
N1-Acetylspermidine-d₆ hydrochloride お問い合わせ
N1-Acetylspermidine hydrochloride (Standard) お問い合わせ

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Human Endogenous Metabolite Microbial Metabolite

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

体外実験

N1-Acetylspermidine (1 mM) hydrochloride is less efficient than Spermidine (HY-B1776) and N⁸-acetylspermidine (HY-113253A) in inducing DNA cleavage at apurinic sites^[3].
N1-Acetylspermidine (500 μM) hydrochloride combined with Procyanidins can increase the proportion of apoptotic SW620 cells (colon cancer cell line)^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

260.20

分子式

C₉H₂₃Cl₂N₃O

CAS 番号

34450-16-3

Appearance

Solid

Color

White to light yellow

SMILES

CC(NCCCNCCCCN)=O.[H]Cl.[H]Cl

Structure Classification

Others

Initial Source

Endogenous metabolite

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 25 mg/mL (96.08 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8432 mL	19.2160 mL	38.4320 mL
5 mM	0.7686 mL	3.8432 mL	7.6864 mL
10 mM	0.3843 mL	1.9216 mL	3.8432 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.13%

Select Batch:

データシート (269 KB) SDS (393 KB)

COA (242 KB) HNMR (281 KB) RP-HPLC (203 KB) MS (183 KB) Elemental Analysis Report (101 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Royo M, et al. Mechanistic studies of mouse polyamine oxidase with N1,N12-bisethylspermine as a substrate. Biochemistry. 2005 May 10;44(18):7079-84. [Content Brief]

[2]. Takenoshita S, et al. Selective elevation of the N1-acetylspermidine level in human colorectal adenocarcinomas. Cancer Res. 1984 Feb;44(2):845-7. [Content Brief]

[3]. Haukanes BI, et al. Action of spermidine, N1-acetylspermidine, and N8-acetylspermidine at apurinic sites in DNA. [Content Brief]

[4]. Kato M, et al. Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils. PNAS Nexus. 2023 Oct 10;2(10):pgad306. [Content Brief]

[5]. Gossé F, et al. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol. 2006 Aug;29(2):423-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8432 mL	19.2160 mL	38.4320 mL	96.0799 mL
	5 mM	0.7686 mL	3.8432 mL	7.6864 mL	19.2160 mL
	10 mM	0.3843 mL	1.9216 mL	3.8432 mL	9.6080 mL
	15 mM	0.2562 mL	1.2811 mL	2.5621 mL	6.4053 mL
	20 mM	0.1922 mL	0.9608 mL	1.9216 mL	4.8040 mL
	25 mM	0.1537 mL	0.7686 mL	1.5373 mL	3.8432 mL
	30 mM	0.1281 mL	0.6405 mL	1.2811 mL	3.2027 mL
	40 mM	0.0961 mL	0.4804 mL	0.9608 mL	2.4020 mL
	50 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.9216 mL
	60 mM	0.0641 mL	0.3203 mL	0.6405 mL	1.6013 mL
	80 mM	0.0480 mL	0.2402 mL	0.4804 mL	1.2010 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.