2. Anti-infection
  3. Bacterial Antibiotic
  4. Oxacillin

Oxacillin is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens.

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CAS No. : 66-79-5

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Oxacillin Related Antibodies

Top Publications Citing Use of Products

    Oxacillin purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141.  [Abstract]

    Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.

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    Description

    Oxacillin is an orally active synthetic penicillin with good bactericidal activity against staphylococci and other gram-positive pathogens[1].

    IC50 & Target

    β-lactam

     

    Cellular Effect
    Cell Line Type Value Description References
    CHO IC50
    35 μM
    Compound: Oxacillin
    Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
    Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
    		[PMID: 23344796]
    In Vitro

    Oxacillin inhibits gram positive pathogens with MICs of 0.05, 0.09, 0.32 and 0.80 μg/mL against group A streptococci, Pneutnococci, susceptible staphylococci and penicillin-resistant staphylococci, respectively[1].
    The Oxacillin-resistant strains are highly resistant to other penicillins[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Oxacillin Related Antibodies
    In Vivo

    Oxacillin (50-800 mg/kg; s.c.; once) shows curative dose (CD50) of 253.3 mg/kg in mice infected with Staphylococcus aureus Evans. The oral CD50 of Oxacillin is 187.2 mg/kg[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: CD-1 strain male albino mice infected with S. aureus Evans[2]
    Dosage: 50, 100, 200, 400 and 800 mg/kg
    Administration: Subcutaneous injection, once
    Result: Showed therapeutic activity with CD50 of 253.3 mg/kg.
    Masse moléculaire

    401.44

    Formule

    C19H19N3O5S
    CAS No.
    SMILES

    O=C([C@@H](C(C)(C)S[C@]1([H])[C@@H]2NC(C3=C(C)ON=C3C4=CC=CC=C4)=O)N1C2=O)O
    Livraison

    Room temperature in continental US; may vary elsewhere.
    Stockage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Pureté et documentation
    Références
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    Oxacillin Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Oxacillin66-79-5BacterialAntibioticorally activestaphylococcigram-positive pathogensStaphylococcus aureusInhibitorinhibitorinhibit

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