Oxacillin sodium monohydrate
Based on 14 publication(s) in Google Scholar
Oxacillin sodium monohydrate is an antibiotic similar to Flucloxacillin used in resistant staphylococci infections study.
For research use only. We do not sell to patients.
- Purity: 99.62%
- CAS No.: 7240-38-2
- Formula: C19H20N3NaO6S
- Molecular Weight:441.43
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Oxacillin sodium monohydrate
More- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Front Microbiol. 2020 Jul 31:11:1720. [Abstract]
- BMC Microbiol. 2023 Apr 20;23(1):109. [Abstract]
- ACS Omega. 2022 Mar 3;7(10):9004-9014. [Abstract]
- Microorganisms. 2024 Jan 25;12(2):256. [Abstract]
- iScience. 2022 Jan 5;25(2):103731. [Abstract]
- Microbiol Spectr. 2022 Apr 27;10(2):e0054121. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- Biomed Res Int. 2018 Jul 2:2018:3579832. [Abstract]
- Curr Microbiol. 2023 May 31;80(7):230. [Abstract]
- bioRxiv. 2025 Oct 27.
- bioRxiv. 2024 May 10.
- Research Square Print. December 5th, 2022.
Customer Validation & Images
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Microbiological Assay
All Antibiotic Isoforms
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Biological Activity
Oxacillin exhibits MIC values of ≤1 μg/mL for four mecA gene-carrying S. aureus clinical isolates (SA 1306, SA 1326, SA 1552, and SA 4666[1].
Oxacillin (5 μg/mL, 0-90 min) induces lysis of Tol+and Tol- strains[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cells of S. aureus which had grown for six to eight generations in [14C]glycerol.
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Concentration:5 μg/mL.
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Incubation Time:0, 30, 60, 90 min.
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Result:The Tol+ isolates were readily distinguished from Tol- isolates by the rates at which the cells lysed.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 7240-38-2
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Appearance Solid
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Molecular Weight 441.43
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Formula C19H20N3NaO6S
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Color White to off-white
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SMILES
O=C(O[Na])[C@@H]1N(C2=O)[C@]([C@@H]2NC(C(C(C3=CC=CC=C3)=NO4)=C4C)=O)([H])SC1(C)C.O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (14)
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Journal Impact Factor
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Most Recent
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Front Microbiol
Repurposing Antispasmodic Agent Otilonium Bromide for Treatment of Staphylococcus aureus Infections. [Abstract]2020 Jul 31:11:1720. PMID: 32849366 -
BMC Microbiol
The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin. [Abstract]2023 Apr 20;23(1):109. PMID: 37081393 -
ACS Omega
Lapatinib Acts against Biofilm Formation and the Hemolytic Activity of Staphylococcus aureus. [Abstract]2022 Mar 3;7(10):9004-9014. PMID: 35309438 -
Microorganisms
The Staphylococcus aureus ArlS Kinase Inhibitor Tilmicosin Has Potent Anti-Biofilm Activity in Both Static and Flow Conditions. [Abstract]2024 Jan 25;12(2):256. PMID: 38399660 -
iScience
2022 Jan 5;25(2):103731. PMID: 35098100 -
Microbiol Spectr
Clemastine Inhibits the Biofilm and Hemolytic of Staphylococcus aureus through the GdpP Protein. [Abstract]2022 Apr 27;10(2):e0054121. PMID: 35234502 -
AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732
Oxacillin sodium monohydrate purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]
Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.
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Biomed Res Int
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Mycobacterium tuberculosis Clinical Isolates. [Abstract]2018 Jul 2:2018:3579832. PMID: 30065936 -
Curr Microbiol
Repurposing CD5789 as an Antimicrobial Agent Against MRSA and Its High Resistant Phonotypes. [Abstract]2023 May 31;80(7):230. PMID: 37256372 -
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Solvent & Solubility
H2O : ≥ 100 mg/mL (226.54 mM)
DMSO : 50 mg/mL (113.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 110 mg/mL (249.19 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Alexandros Ikonomidis, et al. In vitro and in vivo evaluations of oxacillin efficiency against mecA-positive oxacillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2008 Nov;52(11):3905-8. [Content Brief]
[2]. R H Raynor, et al. Oxacillin-induced lysis of Staphylococcus aureus. Antimicrob Agents Chemother. 1979 Aug;16(2):134-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 2.2654 mL | 11.3268 mL | 22.6536 mL | 56.6341 mL |
| 5 mM | 0.4531 mL | 2.2654 mL | 4.5307 mL | 11.3268 mL | |
| 10 mM | 0.2265 mL | 1.1327 mL | 2.2654 mL | 5.6634 mL | |
| 15 mM | 0.1510 mL | 0.7551 mL | 1.5102 mL | 3.7756 mL | |
| 20 mM | 0.1133 mL | 0.5663 mL | 1.1327 mL | 2.8317 mL | |
| 25 mM | 0.0906 mL | 0.4531 mL | 0.9061 mL | 2.2654 mL | |
| 30 mM | 0.0755 mL | 0.3776 mL | 0.7551 mL | 1.8878 mL | |
| 40 mM | 0.0566 mL | 0.2832 mL | 0.5663 mL | 1.4159 mL | |
| 50 mM | 0.0453 mL | 0.2265 mL | 0.4531 mL | 1.1327 mL | |
| 60 mM | 0.0378 mL | 0.1888 mL | 0.3776 mL | 0.9439 mL | |
| 80 mM | 0.0283 mL | 0.1416 mL | 0.2832 mL | 0.7079 mL | |
| 100 mM | 0.0227 mL | 0.1133 mL | 0.2265 mL | 0.5663 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Oxacillin sodium monohydrate Related Classifications
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