2. Metabolic Enzyme/Protease Apoptosis
  3. Phosphodiesterase (PDE) TNF Receptor
  4. PDE4-IN-15

PDE4-IN-15 (compound 7b-1) is an inhibitor of PDE4 (IC50 = 0.17 μM) and has anti-TNF-α activity (EC50 = 0.19 μM). PDE4-IN-15 has a good skin permeability.

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PDE4-IN-15

PDE4-IN-15 Estructura química

No. CAS : 3034837-89-0

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PDE4-IN-15 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF10B/DR5/CD262 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

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Descripciòn

PDE4-IN-15 (compound 7b-1) is an inhibitor of PDE4 (IC50 = 0.17 μM) and has anti-TNF-α activity (EC50 = 0.19 μM). PDE4-IN-15 has a good skin permeability[1].

IC50 & Target

PDE4

 

Cellular Effect
Cell Line Type Value Description References
PBMC CC50
> 180 μM
Compound: 7b-1
Cytotoxicity against human PBMC cells by MTT assay
Cytotoxicity against human PBMC cells by MTT assay
[PMID: 38489246]
PBMC EC50
0.19 μM
Compound: 7b-1
Inhibition of LPS-induced TNF-alpha production in human PBMC cells pretreated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
Inhibition of LPS-induced TNF-alpha production in human PBMC cells pretreated for 1 hr followed by LPS addition and measured after 24 hrs by ELISA
[PMID: 38489246]
Peso molecular

402.48

Fòrmula

C23H30O6
No. CAS
SMILES

OC[C@H]1C2=C(O[C@@H]1C3=CC(OCC)=C(C=C3)OC)C(OCC)=CC(CCCO)=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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PDE4-IN-15 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE4-IN-153034837-89-0Phosphodiesterase (PDE)TNF ReceptorTumor Necrosis Factor ReceptorTNFRPDE4Antiatopic;Inhibitorinhibitorinhibit

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Nombre del producto:
PDE4-IN-15
Cat. No.:
HY-161381
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