1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. PDE9-IN-1

PDE9-IN-1 

Cat. No.: HY-126137
Handling Instructions

PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC50 of 8.7 nM.

For research use only. We do not sell to patients.

PDE9-IN-1 Chemical Structure

PDE9-IN-1 Chemical Structure

CAS No. : 2305087-92-5

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Description

PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC50 of 8.7 nM[1].

IC50 & Target[1]

PDE9A

8.7 nM (IC50)

In Vitro

PDE9-IN-1 is excellent selectivity across PDE families[1].

In Vivo

PDE9-IN-1 (2.5 and 5.0 mg/kg; Oral administration; daily for 21 days) effectively recovers learning and memory function[1].

Animal Model: Unilateral common carotid artery occlusion (UCCAO) mouse model[1]
Dosage: 2.5 and 5.0 mg/kg
Administration: Oral administration; daily for 21 days
Result: Significantly reduced the day 6 escape latency time and increased the frequency of platform area crossings, and recovered learning and memory function. High dose group possibly improved the escape latency time of mice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

362.40

Formula

C₁₇H₂₃FN₆O₂

CAS No.

2305087-92-5

SMILES

O=C1C2=C(N(C3CCCC3)N=C2)N=C(N[[email protected]](C)C(N4CC[[email protected]](F)C4)=O)N1

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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PDE9-IN-1
Cat. No.:
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Cat. No.: HY-126137