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Pioglitazone hydrochloride

(Synonyms: U 72107A; AD 4833)
47 Cited Publications
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Based on 47 publication(s) in Google Scholar

Pioglitazone hydrochloride is a potent and selective PPARγ agonist with EC50s of 0.93 and 0.99 μM for human and mouse PPARγ, respectively.

For research use only. We do not sell to patients.

  • Purity: 99.97%
  • CAS No.: 112529-15-4
  • Formula: C19H21ClN2O3S
  • Molecular Weight:392.90
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)

  • Pioglitazone hydrochloride Chemical Structure
    Pioglitazone hydrochloride Chemical Structure
  • Experimental Validation Results for Pioglitazone hydrochloride
  • Experimental Validation Results for Pioglitazone hydrochloride
  • Experimental Validation Results for Pioglitazone hydrochloride
  • Experimental Validation Results for Pioglitazone hydrochloride
  • Experimental Validation Results for Pioglitazone hydrochloride
  • Experimental Validation Results for Pioglitazone hydrochloride
  • Experimental Validation Results for Pioglitazone hydrochloride
  • Experimental Validation Results for Pioglitazone hydrochloride
CAS No.: 112529-15-4
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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  • Pioglitazone hydrochloride Chemical Structure
    Pioglitazone hydrochloride Chemical Structure
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    Pioglitazone hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Sep 10;16(1):8215. [Abstract]

    Customer Validation
     Western blot for NECTIN4 and HPGD in RT112 cells treated with T0070907, Rosiglitazone, and Pioglitazone (1 μM, 72 h).

  • 1/16

    Pioglitazone hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 25:e2407134. [Abstract]

    Customer Validation
     Decreased expression of collagen I in activated fibroblasts was consistently shown through immunofluorescence staining after administering 3PO and Pioglitazone (10, 20, 30 μM).

  • 1/16

    Pioglitazone hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 11:e08957. [Abstract]

    Customer Validation
     Experimental timelines for behavioral testing following Pioglitazone (15-30 mg/kg, p.o.) treatment. Typical heat plot , social interaction ratio, time in interaction zone.

  • 1/16

    Pioglitazone hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec 25:e2407134. [Abstract]

    Customer Validation
     Histopathological analysis of mouse lung tissue revealed that treatment with Pioglitazone (10, 20, 30 μM) partially mitigated lung fibrosis, although collagen deposits persisted.

  • 1/16

    Pioglitazone hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Nov 11:e08957. [Abstract]

    Customer Validation
     The mRNA expression of inflammatory cytokines Il1b and Il6 decreased in the mPFC from control‐GFP, SUS‐GFP, control‐Pioglitazone and SUS‐Pioglitazone (15-30 mg/kg, p.o.) mice.

  • 1/16

    Pioglitazone hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Stem Cell. 2022 Sep 1;29(9):1366-1381.e9. [Abstract]

    Customer Validation
     Crypts isolated from Lgr5-EGFP-IRES-creERT2 mice were cultured with CA together with/without 100 μM WY14643/ 10 μM Pioglitazone/ 1 μM GW501516 for 6 days. Representative staining pattern of Lgr5+ cells.

  • 1/16

    Pioglitazone hydrochloride purchased from MedChemExpress. Usage Cited in: Inflammation. 2020 Apr;43(2):568-578. [Abstract]

    Customer Validation
     Colonic lysates of CON + Veh, DSS + Veh, and DSS + PIO (day 7, day 14, and day 21) group mice are analyzed by immunoblotting with IL-6, TNF-α, MMP9, and PPARγ antibodies, respectively. Each lane represents one mouse.

  • 1/16

    Pioglitazone hydrochloride purchased from MedChemExpress. Usage Cited in: Inflammation. 2020 Apr;43(2):568-578. [Abstract]

    Customer Validation
     Colonic lysates of CON + Veh, DSS + Veh, and DSS + PIO (day 7, day 14, and day 21) group mice are analyzed by immunoblotting with p-ERK, ERK, p-P65, and P65 antibodies, respectively. Each lane represents one mouse.

  • Pioglitazone hydrochloride