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Cat. No.: HY-139201E

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Poly-D-lysine hydrobromide (MW 150000-300000)

Name: Poly-D-lysine hydrobromide (MW 150000-300000)
Brand: MedChemExpress
SKU: HY-139201E
Price: 207.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: PDLHB (MW 150000-300000))

Customer Review

Based on 1 Customer Validation

Poly-D-lysine hydrobromide (MW 150000-300000) is a synthetic polymer composed of D-lysine residues and is one of the most widely used matrices in neural cell culture applications. Poly-D-lysine hydrobromide (MW 150000-300000) can be used as a non-specific cell adhesion enhancer. Poly-D-lysine hydrobromide (MW 30000-70000) is an orally active CaSR agonist peptide that indirectly activates the 5-HT₃ receptor signaling pathway, delaying gastric emptying and thereby slowing the rate at which glucose enters the small intestine and is absorbed.

For research use only. We do not sell to patients.

CAS No.: 27964-99-4
Formula: (C₆H₁₄N₂O₂)n.xHBr
Molecular Weight:150000-300000

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Poly-D-lysine hydrobromide (MW 150000-300000) Chemical Structure

CAS No.: 27964-99-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All 5-HT Receptor Isoforms :

In Vitro

Poly-D-lysine hydrobromide (0.1 mg/mL,0-24 h) promotes the formation of strong and stable adhesion plaques in primary cultured rat pulmonary artery smooth muscle cells (PASMCs), while restricting their migration ability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay^[2]

Cell Line:

PASMCs
Concentration:

0.1 mg/mL
Incubation Time:

0, 8, 12, 24 h
Result:

Inhibited cell migration.

In Vivo

Poly-D-lysine hydrobromide (MW 30000-70000) (50 mg/kg, i.g or duodenum administration, single dose) reduces the peak blood glucose level after oral glucose administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Oral glucose tolerance test (OGTT) and intraperitoneal glucose tolerance test (IPGTT) established in male Sprague-Dawley rats (7 weeks old), weighing 210-230 g^[1]
Dosage:

50 mg/kg
Administration:

Oral gavage (i.g.) or duodenum administration, single dose
Result:

Significantly reduced the peak blood glucose level after oral glucose administration, but had no significant hypoglycemic effect in the intraperitoneal glucose tolerance test (IPGTT).
Delayed the absorption of glucose by slowing down the rate at which food moves from the stomach to the small intestine.

Chemical Information

CAS No. 27964-99-4
Appearance Solid
Molecular Weight 150000-300000
Formula (C₆H₁₄N₂O₂)n.xHBr
Color White to off-white
SMILES

CNC(CCCCN)C(N[C@@H](CCCCN)C(N[C@H](CCCCN)C(C)=O)=O)=O.[x].Br.[n]
Synonyms

PDLHB (MW 150000-300000)
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Maya Muramatsu, et al. Activation of the gut calcium-sensing receptor by peptide agonists reduces rapid elevation of plasma glucose in response to oral glucose load in rats. Am J Physiol Gastrointest Liver Physiol. 2014 Jun 15;306(12):G1099-107. [Content Brief]

[2]. Wang F, et al. [Migratory properties of vascular smooth muscle cells on extracellular matrix: a study on inverted coverslip migration assay]. Sheng Li Xue Bao. 2013 Apr 25;65(2):135-42. Chinese. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

Poly-D-lysine hydrobromide (MW 150000-300000)

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Poly-D-lysine hydrobromide (MW 150000-300000)

Poly-D-lysine hydrobromide (MW 70000-150000)

Poly-D-lysine hydrobromide (MW 30000-70000)

Poly-D-lysine hydrobromide (MW 84000)

Poly-D-lysine hydrobromide (MW 4000-15000)

Poly-D-lysine hydrobromide (MW ≥300000)

Poly-L-lysine solution (0.01%, sterile-filtered, MW 150000-300000)

Poly-L-lysine hydrobromide (MW 15000-30000)

Poly-L-lysine hydrobromide (MW 4000-15000)

Poly-L-lysine solution (0.01%, sterile-filtered, MW 70000-150000)

Poly-L-lysine hydrobromide (MW 70000-150000)

Poly-L-lysine hydrobromide (MW 150000-300000)

Poly-D-lysine hydrobromide (MW 1000-5000)

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Poly-D-lysine hydrobromide (MW 150000-300000)

Poly-D-lysine hydrobromide (MW 70000-150000)

Poly-D-lysine hydrobromide (MW 30000-70000)

Poly-D-lysine hydrobromide (MW 84000)

Poly-D-lysine hydrobromide (MW 4000-15000)

Poly-D-lysine hydrobromide (MW ≥300000)

Poly-L-lysine solution (0.01%, sterile-filtered, MW 150000-300000)

Poly-L-lysine hydrobromide (MW 15000-30000)

Poly-L-lysine hydrobromide (MW 4000-15000)

Poly-L-lysine solution (0.01%, sterile-filtered, MW 70000-150000)

Poly-L-lysine hydrobromide (MW 70000-150000)

Poly-L-lysine hydrobromide (MW 150000-300000)

Poly-D-lysine hydrobromide (MW 1000-5000)

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Poly-D-lysine hydrobromide (MW 150000-300000) Related Classifications

HY-139201E Related Classifications

Bioz