Prifinium bromide

Name: Prifinium bromide
Brand: MedChemExpress
SKU: HY-122086
Rating: 4.5 (0 reviews)

Cat. No.: HY-122086 Pureza: 99.41%: Ficha de datos
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Prifinium bromide is an anticholinergic drug with anticholinergic and antispasmodic activities, and it exhibits oral activity. Prifinium bromide competitively antagonizes cholinergic receptors and relieves symptoms of spasm or hypermotility in the digestive and urinary tracts, with its anticholinergic activity representing the core mechanism underlying the inhibition of bladder smooth muscle contraction. Prifinium bromide can be used in research related to spasms and diverticular disease.

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Prifinium bromide Estructura química

No. CAS : 4630-95-9

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	Obtener un presupuesto	Estimated Time of Arrival: December 31
1 g	Obtener un presupuesto	Estimated Time of Arrival: December 31
5 g	Obtener un presupuesto	Estimated Time of Arrival: December 31
10 g	Obtener un presupuesto
50 g	Obtener un presupuesto

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Descripciòn

In Vitro

Prifinium bromide inhibits carbamoylcholine chloride (HY-B1208)-induced contraction of isolated guinea pig detrusor muscle, but exerts almost no effect on contractions induced by electrical stimulation, KCl or BaCl₂^[1].
Prifinium bromide exhibits anticholinergic activity in isolated guinea pig ileum, with a relative potency of 0.45 compared with Atropine (HY-B1205)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

386.37

Fòrmula

C₂₂H₂₈BrN

No. CAS

4630-95-9

Appearance

Solid

Color

White to off-white

SMILES

CC1[N+](CC)(CC/C1=C(C2=CC=CC=C2)\C3=CC=CC=C3)CC.[Br-]

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (258.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5882 mL	12.9410 mL	25.8819 mL
5 mM	0.5176 mL	2.5882 mL	5.1764 mL
10 mM	0.2588 mL	1.2941 mL	2.5882 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.41%

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Ficha de datos (276 KB) SDS (393 KB)

COA (254 KB) HNMR (167 KB) LCMS (102 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Terai T, et al. Effects of the anticholinergic drug prifinium bromide on urinary bladder contractions in rat in vivo and in guinea-pig in vitro. Arzneimittelforschung. 1991;41(4):417-420. [Content Brief]

[2]. Ohki S, et al. Synthesis of Pyrrolidine Derivatives with Pharmacological Activity. XII. Synthesis and Anticholinergic Activity of 1,1-Dialkyl-3-diphenylmethylene-2,4-dimethylpyrrolidinium Halides. Chem Pharm Bull. 1986;34(9):3606-3613. [Content Brief]

[3]. Sasaki D, et al. Anti-spasmodic effect of prifinium bromide on the proximal and distal colon in patients with diverticular disease. Gastroenterol Jpn. 1981;16(4):344-349. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5882 mL	12.9410 mL	25.8819 mL	64.7048 mL
	5 mM	0.5176 mL	2.5882 mL	5.1764 mL	12.9410 mL
	10 mM	0.2588 mL	1.2941 mL	2.5882 mL	6.4705 mL
	15 mM	0.1725 mL	0.8627 mL	1.7255 mL	4.3137 mL
	20 mM	0.1294 mL	0.6470 mL	1.2941 mL	3.2352 mL
	25 mM	0.1035 mL	0.5176 mL	1.0353 mL	2.5882 mL
	30 mM	0.0863 mL	0.4314 mL	0.8627 mL	2.1568 mL
	40 mM	0.0647 mL	0.3235 mL	0.6470 mL	1.6176 mL
	50 mM	0.0518 mL	0.2588 mL	0.5176 mL	1.2941 mL
	60 mM	0.0431 mL	0.2157 mL	0.4314 mL	1.0784 mL
	80 mM	0.0324 mL	0.1618 mL	0.3235 mL	0.8088 mL
	100 mM	0.0259 mL	0.1294 mL	0.2588 mL	0.6470 mL