2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. mAChR iGluR
  4. Procyclidine

Procyclidine  (Synonyms: Tricyclamol; (±)-Procyclidine)

Cat. No.: HY-B1487A
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Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy.

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Procyclidine

Procyclidine 화학구조

CAS No. : 77-37-2

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Procyclidine Related Antibodies

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제품 설명

Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy[1][2].

IC50 & Target

NMDA Receptor

 

In Vivo

Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs[1]
Dosage: 0.3-6.0 mg/kg
Administration: Subcutaneous injection; once
Result: Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.
Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.
분자량

287.44

화학식

C19H29NO
CAS No.
SMILES

OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Procyclidine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Procyclidine77-37-2Tricyclamol (±)-ProcyclidinemAChRiGluRMuscarinic acetylcholine receptorIonotropic glutamate receptorsmuscarinic receptorNMDAanticholinergicParkinson's diseaseepilepsySomanInhibitorinhibitorinhibit

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Procyclidine
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HY-B1487A
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